STOCK Grin1tm1a(EUCOMM)Wtsi/WtsiOrl

Status

Available to order

EMMA IDEM:05794
Citation informationRRID:IMSR_EM:05794 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Grin1tm1a(EUCOMM)Wtsi/WtsiOrl
Alternative nameEPD0469_5_C11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGrin1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolGrin1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0469_5_C11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • thrombocytopenia / IMPC
  • decreased circulating potassium level / IMPC
IMPC phenotypes (gene matching)
  • thrombocytopenia / IMPC
  • decreased circulating potassium level / IMPC
MGI phenotypes (allele matching)
  • thrombocytopenia / MGI
MGI phenotypes (gene matching)
  • abnormal trigeminal nerve morphology / MGI
  • atelectasis / MGI
  • lung hemorrhage / MGI
  • overexpanded pulmonary alveoli / MGI
  • decreased body weight / MGI
  • abnormal social investigation / MGI
  • social withdrawal / MGI
  • abnormal anxiety-related response / MGI
  • reduced male mating frequency / MGI
  • abnormal pup retrieval / MGI
  • pup cannibalization / MGI
  • abnormal maternal nurturing / MGI
  • abnormal locomotor behavior / MGI
  • ataxia / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • stereotypic behavior / MGI
  • increased exploration in new environment / MGI
  • absent suckling reflex / MGI
  • abnormal suckling behavior / MGI
  • aphagia / MGI
  • abnormal nest building behavior / MGI
  • abnormal huddling behavior / MGI
  • abnormal spatial learning / MGI
  • reduced long term potentiation / MGI
  • increased startle reflex / MGI
  • impaired righting response / MGI
  • cyanosis / MGI
  • postnatal growth retardation / MGI
  • absence of NMDA-mediated synaptic currents / MGI
  • reduced male fertility / MGI
  • abnormal respiration / MGI
  • abnormal breathing pattern / MGI
  • respiratory distress / MGI
  • apnea / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal social/conspecific interaction / MGI
  • decreased vertical activity / MGI
  • abnormal conditioned taste aversion behavior / MGI
  • abnormal glutamate-mediated receptor currents / MGI
  • decreased susceptibility to pharmacologically induced seizures / MGI
  • abnormal NMDA-mediated synaptic currents / MGI
  • no phenotypic analysis / MGI
  • thrombocytopenia / MGI
  • increased alcohol consumption / MGI
  • decreased alcohol consumption / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system physiology / MGI
  • decreased aggression towards mice / MGI
  • impaired passive avoidance behavior / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • abnormal neuron physiology / MGI
  • abnormal brainstem morphology / MGI
  • cardiovascular system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • taste/olfaction phenotype / MGI
  • abnormal food intake / MGI
  • abnormal pulmonary respiratory rate / MGI
  • decreased susceptibility to neuronal excitotoxicity / MGI
  • abnormal physiological response to xenobiotic / MGI
  • decreased prepulse inhibition / MGI
  • abnormal maternal grooming / MGI
  • absent gastric milk in neonates / MGI
  • abnormal behavioral response to xenobiotic / MGI
  • reduced AMPA-mediated synaptic currents / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • abnormal behavioral response to alcohol / MGI

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Availabilities

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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