STOCK Ptpn2tm1a(EUCOMM)Wtsi/WtsiBiat

Status

Available to order

EMMA IDEM:05723
Citation informationRRID:IMSR_EM:05723 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Ptpn2tm1a(EUCOMM)Wtsi/WtsiBiat
Alternative nameEPD0445_4_E01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPtpn2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolPtpn2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0445_4_E01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased hemoglobin content / IMPC
  • lipid deposition / IMPC
IMPC phenotypes (gene matching)
  • increased hemoglobin content / IMPC
  • lipid deposition / IMPC
MGI phenotypes (allele matching)
  • increased mean corpuscular hemoglobin / MGI
  • increased hemoglobin content / MGI
MGI phenotypes (gene matching)
  • increased bone mineral density / MGI
  • abnormal bone marrow cell number / MGI
  • decreased hematocrit / MGI
  • abnormal erythropoiesis / MGI
  • decreased bone marrow cell number / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • enlarged lymph nodes / MGI
  • decreased thymocyte number / MGI
  • decreased body size / MGI
  • hypoactivity / MGI
  • abnormal pilomotor reflex / MGI
  • hunched posture / MGI
  • anemia / MGI
  • postnatal growth retardation / MGI
  • abnormal thymus involution / MGI
  • abnormal inflammatory response / MGI
  • increased inflammatory response / MGI
  • premature death / MGI
  • abnormal T cell differentiation / MGI
  • abnormal lymph node morphology / MGI
  • abnormal bone marrow cell morphology/development / MGI
  • abnormal B cell number / MGI
  • decreased erythrocyte cell number / MGI
  • short femur / MGI
  • increased pre-B cell number / MGI
  • thymus atrophy / MGI
  • abnormal long bone morphology / MGI
  • abnormal bone structure / MGI
  • abnormal T cell subpopulation ratio / MGI
  • decreased lean body mass / MGI
  • abnormal negative T cell selection / MGI
  • abnormal positive T cell selection / MGI
  • decreased B-1 B cell number / MGI
  • increased B cell number / MGI
  • decreased B cell number / MGI
  • decreased T cell number / MGI
  • diarrhea / MGI
  • decreased double-positive T cell number / MGI
  • narrow eye opening / MGI
  • skeleton phenotype / MGI
  • hematopoietic system phenotype / MGI
  • increased macrophage cell number / MGI
  • abnormal skeleton morphology / MGI
  • increased mean corpuscular hemoglobin / MGI
  • increased hemoglobin content / MGI
  • decreased long bone epiphyseal plate size / MGI
  • abnormal long bone epiphyseal ossification zone morphology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • lymph node hyperplasia / MGI
  • decreased diameter of femur / MGI
  • decreased follicular B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • increased mature B cell number / MGI
  • decreased mature B cell number / MGI
  • decreased immature B cell number / MGI
  • increased spleen red pulp amount / MGI
  • increased tumor necrosis factor secretion / MGI
  • increased interferon-gamma secretion / MGI
  • increased interleukin-12 secretion / MGI
  • decreased erythroid progenitor cell number / MGI
  • increased splenocyte number / MGI
  • decreased total body fat amount / MGI
  • decreased bone mineral content / MGI
  • abnormal bone trabecula morphology / MGI
  • increased bone trabecula number / MGI
  • increased trabecular bone volume / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • abnormal ossification involved in bone maturation / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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