C57BL/6NTac-Ehd1tm1a(EUCOMM)Wtsi/WtsiBiat

Status

Available to order

EMMA IDEM:05712
International strain nameC57BL/6NTac-Ehd1tm1a(EUCOMM)Wtsi/WtsiBiat
Alternative nameEPD0114_1_D05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolEhd1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolEhd1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0114_1_D05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased circulating LDL cholesterol level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased circulating chloride level / IMPC
  • abnormal eyelid aperture / IMPC
  • increased circulating cholesterol level / IMPC
  • process of degenerative change / IMPC
  • developmental dysplasia / IMPC
IMPC phenotypes (gene matching)
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating chloride level / IMPC
  • developmental dysplasia / IMPC
  • increased circulating LDL cholesterol level / IMPC
  • increased circulating alanine transaminase level / IMPC
  • abnormal eyelid aperture / IMPC
  • process of degenerative change / IMPC
MGI phenotypes (allele matching)
  • increased circulating chloride level / MGI
  • increased mean corpuscular hemoglobin / MGI
  • abnormal eyelid aperture / MGI
MGI phenotypes (gene matching)
  • malocclusion / MGI
  • seminiferous tubule degeneration / MGI
  • abnormal spermatogenesis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • cataract / MGI
  • male infertility / MGI
  • no abnormal phenotype detected / MGI
  • abnormal germ cell morphology / MGI
  • no phenotypic analysis / MGI
  • increased circulating chloride level / MGI
  • abnormal cell migration / MGI
  • abnormal eyelid aperture / MGI
  • abnormal spermiation / MGI
  • decreased testis weight / MGI
  • azoospermia / MGI
  • abnormal male meiosis / MGI
  • cellular phenotype / MGI
  • increased mean corpuscular hemoglobin / MGI
  • abnormal cell physiology / MGI
  • abnormal spermatogonia morphology / MGI
  • abnormal spermatocyte morphology / MGI
  • abnormal spermatid morphology / MGI
  • arrest of spermiogenesis / MGI
  • abnormal male germ cell apoptosis / MGI
  • abnormal acrosome morphology / MGI
  • abnormal Sertoli cell phagocytosis / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • decreased fibroblast cell migration / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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