B6.129P2-Creb1tm4Gsc/Cnrm

Status

Available to order

EMMA IDEM:00571
International strain nameB6.129P2-Creb1tm4Gsc/Cnrm
Alternative nameCREB Ser142
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolCreb1tm4Gsc
Gene/Transgene symbolCreb1

Information from provider

ProviderGünther Schütz
Provider affiliationMolecular Biology of the Cell I, German Cancer Research Center
Genetic informationReplacement of Creb1 Ser142 by Ala by homologous recombination.
Phenotypic informationPhase shift of the circadian clock.
References
  • Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock.;Gau Daniel, Lemberger Thomas, von Gall Charlotte, Kretz Oliver, Le Minh Nguyet, Gass Peter, Schmid Wolfgang, Schibler Ueli, Korf Horst W, Schütz Günther, ;2002;Neuron;34;245-53; 11970866

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal circadian behavior phase / MGI
MGI phenotypes (gene matching)
  • abnormal myogenesis / MGI
  • abnormal muscle regeneration / MGI
  • small superior cervical ganglion / MGI
  • abnormal stellate ganglion morphology / MGI
  • abnormal lung development / MGI
  • abnormal cued conditioning behavior / MGI
  • abnormal spatial learning / MGI
  • abnormal temporal memory / MGI
  • abnormal contextual conditioning behavior / MGI
  • reduced long term potentiation / MGI
  • postnatal lethality / MGI
  • abnormal CNS synaptic transmission / MGI
  • decreased vertical activity / MGI
  • abnormal single cell response / MGI
  • small lung / MGI
  • abnormal lung vasculature morphology / MGI
  • decreased fetal size / MGI
  • muscle phenotype / MGI
  • impaired lung alveolus development / MGI
  • decreased survivor rate / MGI
  • abnormal behavioral response to addictive substance / MGI
  • decreased behavioral withdrawal response / MGI
  • pale lung / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • abnormal circadian behavior phase / MGI

Literature references

  • Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock.;Gau Daniel, Lemberger Thomas, von Gall Charlotte, Kretz Oliver, Le Minh Nguyet, Gass Peter, Schmid Wolfgang, Schibler Ueli, Korf Horst W, Schütz Günther, ;2002;Neuron;34;245-53; 11970866

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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