MGI phenotypes (allele matching)
- abnormal circadian behavior phase / MGI
B6.129P2-Creb1tm4Gsc/Cnrm
| Status | Available to order |
| EMMA ID | EM:00571 |
| Citation information | RRID:IMSR_EM:00571 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Creb1tm4Gsc/Cnrm |
| Alternative name | CREB Ser142 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Creb1tm4Gsc |
| Gene/Transgene symbol | Creb1 |
Information from provider
| Provider | Günther Schütz |
| Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
| Genetic information | Replacement of Creb1 Ser142 by Ala by homologous recombination. |
| Phenotypic information | Phase shift of the circadian clock. |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal myogenesis / MGI
- abnormal muscle regeneration / MGI
- small superior cervical ganglion / MGI
- abnormal stellate ganglion morphology / MGI
- abnormal lung development / MGI
- abnormal cued conditioning behavior / MGI
- abnormal spatial learning / MGI
- abnormal temporal memory / MGI
- abnormal contextual conditioning behavior / MGI
- reduced long term potentiation / MGI
- postnatal lethality / MGI
- abnormal CNS synaptic transmission / MGI
- decreased vertical activity / MGI
- abnormal single cell response / MGI
- small lung / MGI
- abnormal lung vasculature morphology / MGI
- decreased fetal size / MGI
- muscle phenotype / MGI
- impaired lung alveolus development / MGI
- decreased survivor rate / MGI
- abnormal behavioral response to addictive substance / MGI
- decreased behavioral withdrawal response / MGI
- pale lung / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- abnormal circadian behavior phase / MGI
Literature references
- Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock.;Gau Daniel, Lemberger Thomas, von Gall Charlotte, Kretz Oliver, Le Minh Nguyet, Gass Peter, Schmid Wolfgang, Schibler Ueli, Korf Horst W, Schütz Günther, ;2002;Neuron;34;245-53; 11970866