C57BL/6NTac-Adam19tm1a(EUCOMM)Hmgu/Cnrm

Status

Available to order

EMMA IDEM:05664
International strain nameC57BL/6NTac-Adam19tm1a(EUCOMM)Hmgu/Cnrm
Alternative nameHEPD0536_5_C08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAdam19tm1a(EUCOMM)Hmgu
Gene/Transgene symbolAdam19
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0536_5_C08. For further details on the construction of this clone see the page at the IKMC portal. Removal of the targeting cassette using Flp recombinase is required to convert the targeted into a conditional allele - more information on conversion to the b,c and d allele forms. Click here for more information on EUCOMM final vectors
Phenotypic informationPotential EUMODIC data in the Europhenome database
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • overriding aortic valve / MGI
  • abnormal heart valve morphology / MGI
  • abnormal mitral valve morphology / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • decreased atrioventricular cushion size / MGI
  • abnormal adrenal gland morphology / MGI
  • abnormal skeletal muscle morphology / MGI
  • thin diaphragm muscle / MGI
  • edema / MGI
  • hemorrhage / MGI
  • abnormal tricuspid valve morphology / MGI
  • abnormal aortic valve morphology / MGI
  • abnormal pulmonary valve morphology / MGI
  • dilated heart right ventricle / MGI
  • abnormal heart ventricle morphology / MGI
  • skeleton phenotype / MGI
  • abnormal vascular smooth muscle morphology / MGI
  • abnormal vascular endothelial cell morphology / MGI
  • aortic valve stenosis / MGI
  • abnormal cardiac outflow tract development / MGI
  • pulmonary valve stenosis / MGI
  • pregnancy-related premature death / MGI
  • atrial septal defect / MGI
  • perimembraneous ventricular septal defect / MGI
  • heart right ventricle aneurysm / MGI
  • aortopulmonary window / MGI
  • thick aortic valve cusps / MGI
  • thick aortic valve / MGI
  • thick pulmonary valve cusps / MGI
  • thick tricuspid valve / MGI
  • postnatal lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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