B6NTac;B6N-Atm1Brd Barx2tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:05650
International strain nameB6NTac;B6N-Atm1Brd Barx2tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0634_2_F07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolBarx2tm1a(EUCOMM)Hmgu
Gene/Transgene symbolBarx2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0634_2_F07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • absent vibrissae / IMPC
  • abnormal gait / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • increased circulating bilirubin level / IMPC
  • increased circulating amylase level / IMPC
  • abnormal eye morphology / IMPC
  • increased circulating creatine kinase level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • abnormal tail morphology / IMPC
  • abnormal vertebrae morphology / IMPC
MGI phenotypes (gene matching)
  • alopecia / MGI
  • short hair / MGI
  • abnormal hair cycle / MGI
  • enlarged sebaceous gland / MGI
  • abnormal muscle regeneration / MGI
  • abnormal skeletal muscle morphology / MGI
  • thin diaphragm muscle / MGI
  • decreased body weight / MGI
  • short vibrissae / MGI
  • eyelids open at birth / MGI
  • abnormal gait / MGI
  • disheveled coat / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • abnormal skin pigmentation / MGI
  • abnormal skeletal muscle fiber morphology / MGI
  • abnormal muscle fiber morphology / MGI
  • abnormal spine curvature / MGI
  • decreased skeletal muscle mass / MGI
  • slow postnatal weight gain / MGI
  • decreased skeletal muscle fiber diameter / MGI
  • increased variability of skeletal muscle fiber size / MGI
  • skeletal muscle fiber atrophy / MGI
  • skeletal muscle fibrosis / MGI
  • decreased skeletal muscle weight / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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