- abnormal malleus morphology / MGI
- absent mandible / MGI
- abnormal basisphenoid bone morphology / MGI
- abnormal craniofacial morphology / MGI
- abnormal head morphology / MGI
- microcephaly / MGI
- abnormal cranium morphology / MGI
- abnormal snout morphology / MGI
- short snout / MGI
- abnormal mandible morphology / MGI
- abnormal inferior colliculus morphology / MGI
- abnormal forebrain morphology / MGI
- forebrain hypoplasia / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal third ventricle morphology / MGI
- abnormal diencephalon morphology / MGI
- abnormal hindbrain morphology / MGI
- abnormal metencephalon morphology / MGI
- abnormal midbrain morphology / MGI
- abnormal trigeminal V mesencephalic nucleus morphology / MGI
- abnormal brain development / MGI
- exencephaly / MGI
- open neural tube / MGI
- abnormal oculomotor nerve morphology / MGI
- abnormal trochlear nerve morphology / MGI
- abnormal trigeminal nerve morphology / MGI
- decreased body size / MGI
- anophthalmia / MGI
- microphthalmia / MGI
- abnormal eye distance/ position / MGI
- abnormal iris morphology / MGI
- abnormal retina morphology / MGI
- decreased retinal photoreceptor cell number / MGI
- abnormal optic nerve morphology / MGI
- abnormal eyelid morphology / MGI
- abnormal embryo development / MGI
- abnormal ectoderm development / MGI
- abnormal mesoderm development / MGI
- abnormal axial mesoderm / MGI
- abnormal somite development / MGI
- abnormal somite shape / MGI
- abnormal gastrulation / MGI
- decreased embryo size / MGI
- abnormal visceral yolk sac morphology / MGI
- abnormal allantois morphology / MGI
- embryonic growth arrest / MGI
- anencephaly / MGI
- reduced fertility / MGI
- reduced male fertility / MGI
- decreased litter size / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal eye morphology / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- small heart / MGI
- abnormal primitive streak formation / MGI
- abnormal nasal cavity morphology / MGI
- abnormal nasal septum morphology / MGI
- abnormal vomeronasal organ morphology / MGI
- abnormal nasopharynx morphology / MGI
- micrognathia / MGI
- abnormal sclera morphology / MGI
- decreased circulating luteinizing hormone level / MGI
- abnormal notochord morphology / MGI
- aphakia / MGI
- abnormal forebrain development / MGI
- abnormal alisphenoid bone morphology / MGI
- absent olfactory bulb / MGI
- nervous system phenotype / MGI
- abnormal retinal layer morphology / MGI
- abnormal facial morphology / MGI
- abnormal palate morphology / MGI
- abnormal nervous system development / MGI
- abnormal midbrain development / MGI
- absent pharyngeal arches / MGI
- abnormal craniofacial development / MGI
- embryonic growth retardation / MGI
- abnormal rod electrophysiology / MGI
- abnormal cone electrophysiology / MGI
- abnormal primitive node morphology / MGI
- abnormal midbrain-hindbrain boundary development / MGI
- abnormal adenohypophysis morphology / MGI
- abnormal embryonic neuroepithelium morphology / MGI
- abnormal presphenoid bone morphology / MGI
- abnormal pterygoid bone morphology / MGI
- basisphenoid bone foramen / MGI
- absent maxilla / MGI
- small mandible / MGI
- abnormal nasal capsule morphology / MGI
- decreased testis weight / MGI
- absent nasal septum / MGI
- absent mandibular coronoid process / MGI
- abnormal ciliary ganglion morphology / MGI
- abnormal amnion morphology / MGI
- abnormal incus morphology / MGI
- holoprosencephaly / MGI
- abnormal anterior eye segment morphology / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal rostral-caudal axis patterning / MGI
- abnormal extraocular muscle morphology / MGI
- aniridia / MGI
- absent pituitary gland / MGI
- small cranium / MGI
- embryo phenotype / MGI
- craniofacial phenotype / MGI
- reproductive system phenotype / MGI
- vision/eye phenotype / MGI
- retinal pigment epithelium hyperplasia / MGI
- abnormal Meckel's cartilage morphology / MGI
- abnormal horizontal cell morphology / MGI
- abnormal retinal bipolar cell morphology / MGI
- abnormal hindbrain development / MGI
- decreased visual acuity / MGI
- absent nasal placodes / MGI
- absent optic vesicle / MGI
- decreased retinal ganglion cell number / MGI
- abnormal first pharyngeal arch morphology / MGI
- abnormal gonadotroph morphology / MGI
- decreased gonadotroph cell number / MGI
- absent nasal capsule / MGI
- decreased retinal cone cell number / MGI
- thin retinal inner nuclear layer / MGI
- thin retinal outer nuclear layer / MGI
- abnormal olfactory epithelium morphology / MGI
- absent choroid plexus / MGI
- abnormal mesendoderm development / MGI
- otocephaly / MGI
- acephaly / MGI
- abnormal pretectal region morphology / MGI
- impaired somite development / MGI
- absent tongue / MGI
- mortality/aging / MGI
- abnormal maxillary prominence morphology / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal cephalic neural fold morphology / MGI
- absent heart / MGI
- fused somites / MGI
- absent foregut / MGI
- absent midbrain / MGI
- decreased midbrain size / MGI
- midbrain hypoplasia / MGI
- abnormal midbrain-hindbrain boundary morphology / MGI
- embryonic-extraembryonic boundary constriction / MGI
- absent forebrain / MGI
- decreased forebrain size / MGI
- rostral body truncation / MGI
- absent cornea / MGI
- absent prechordal mesoderm / MGI
- absent metencephalon / MGI
- absent diencephalon / MGI
- abnormal primitive streak elongation / MGI
- decreased embryonic neuroepithelium thickness / MGI
- absent vomeronasal organ / MGI
- absent embryonic telencephalon / MGI
- abnormal visceral yolk sac endoderm morphology / MGI
- abnormal visceral yolk sac mesenchyme morphology / MGI
- absent orbitosphenoid bone / MGI
- abnormal temporal bone tympanic part morphology / MGI
- abnormal anterior head development / MGI
STOCK Otx2tm1.1(cre/ERT2)Mgoe/Cnrm
Status | Available to order |
EMMA ID | EM:05640 |
Citation information | RRID:IMSR_EM:05640 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | STOCK Otx2tm1.1(cre/ERT2)Mgoe/Cnrm |
Alternative name | Otx2-CreER |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Otx2tm1.1(cre/ERT2)Mgoe |
Gene/Transgene symbol | Otx2 |
Information from provider
Provider | Antonio Simeone |
Provider affiliation | Ceinge Biotecnologie Avanzate |
Genetic information | The Otx2 allele is replaced with CreER gene by homologous recombination. |
Phenotypic information | By 9.5 dpc, homozygous mutant embryos are characterized by the absence of forebrain and midbrain regions. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Combined pituitary hormone deficiencies, genetic forms / Orphanet_95494
- Butterfly-shaped pigment dystrophy / Orphanet_99001
- Colobomatous microphthalmia / Orphanet_98938
- Nanophthalmos / Orphanet_35612
- Syndromic microphthalmia type 5 / Orphanet_178364
- Septo-optic dysplasia spectrum / Orphanet_3157
MGI phenotypes (gene matching)
Literature references
- The transcription factor Otx2 regulates choroid plexus development and function.;Johansson Pia A, Irmler Martin, Acampora Dario, Beckers Johannes, Simeone Antonio, Götz Magdalena, ;2013;Development (Cambridge, England);140;1055-66; 23364326
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).