STOCK Otx2tm1.1(cre/ERT2)Mgoe/Cnrm

Status

Available to order

EMMA IDEM:05640
International strain nameSTOCK Otx2tm1.1(cre/ERT2)Mgoe/Cnrm
Alternative nameOtx2-CreER
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolOtx2tm1.1(cre/ERT2)Mgoe
Gene/Transgene symbolOtx2

Information from provider

ProviderAntonio Simeone
Provider affiliationCeinge Biotecnologie Avanzate
Genetic informationThe Otx2 allele is replaced with CreER gene by homologous recombination.
Phenotypic informationBy 9.5 dpc, homozygous mutant embryos are characterized by the absence of forebrain and midbrain regions.
References
  • The transcription factor Otx2 regulates choroid plexus development and function.;Johansson Pia A, Irmler Martin, Acampora Dario, Beckers Johannes, Simeone Antonio, Götz Magdalena, ;2013;Development (Cambridge, England);140;1055-66; 23364326
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal malleus morphology / MGI
  • absent mandible / MGI
  • abnormal basisphenoid bone morphology / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal head morphology / MGI
  • microcephaly / MGI
  • abnormal cranium morphology / MGI
  • abnormal snout morphology / MGI
  • short snout / MGI
  • abnormal mandible morphology / MGI
  • abnormal inferior colliculus morphology / MGI
  • abnormal forebrain morphology / MGI
  • forebrain hypoplasia / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal third ventricle morphology / MGI
  • abnormal diencephalon morphology / MGI
  • abnormal hindbrain morphology / MGI
  • abnormal metencephalon morphology / MGI
  • abnormal midbrain morphology / MGI
  • abnormal trigeminal V mesencephalic nucleus morphology / MGI
  • abnormal brain development / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • abnormal oculomotor nerve morphology / MGI
  • abnormal trochlear nerve morphology / MGI
  • abnormal trigeminal nerve morphology / MGI
  • decreased body size / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • abnormal eye distance/ position / MGI
  • abnormal iris morphology / MGI
  • abnormal retina morphology / MGI
  • decreased retinal photoreceptor cell number / MGI
  • abnormal optic nerve morphology / MGI
  • abnormal eyelid morphology / MGI
  • abnormal embryo development / MGI
  • abnormal ectoderm development / MGI
  • abnormal mesoderm development / MGI
  • abnormal axial mesoderm / MGI
  • abnormal somite development / MGI
  • abnormal somite shape / MGI
  • abnormal gastrulation / MGI
  • decreased embryo size / MGI
  • abnormal visceral yolk sac morphology / MGI
  • abnormal allantois morphology / MGI
  • embryonic growth arrest / MGI
  • anencephaly / MGI
  • reduced fertility / MGI
  • reduced male fertility / MGI
  • decreased litter size / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • abnormal developmental patterning / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal eye morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • small heart / MGI
  • abnormal primitive streak formation / MGI
  • abnormal nasal cavity morphology / MGI
  • abnormal nasal septum morphology / MGI
  • abnormal vomeronasal organ morphology / MGI
  • abnormal nasopharynx morphology / MGI
  • micrognathia / MGI
  • abnormal sclera morphology / MGI
  • decreased circulating luteinizing hormone level / MGI
  • abnormal notochord morphology / MGI
  • aphakia / MGI
  • abnormal forebrain development / MGI
  • abnormal alisphenoid bone morphology / MGI
  • absent olfactory bulb / MGI
  • nervous system phenotype / MGI
  • abnormal retinal layer morphology / MGI
  • abnormal facial morphology / MGI
  • abnormal palate morphology / MGI
  • abnormal nervous system development / MGI
  • abnormal midbrain development / MGI
  • absent pharyngeal arches / MGI
  • abnormal craniofacial development / MGI
  • embryonic growth retardation / MGI
  • abnormal rod electrophysiology / MGI
  • abnormal cone electrophysiology / MGI
  • abnormal primitive node morphology / MGI
  • abnormal midbrain-hindbrain boundary development / MGI
  • abnormal adenohypophysis morphology / MGI
  • abnormal embryonic neuroepithelium morphology / MGI
  • abnormal presphenoid bone morphology / MGI
  • abnormal pterygoid bone morphology / MGI
  • basisphenoid bone foramen / MGI
  • absent maxilla / MGI
  • small mandible / MGI
  • abnormal nasal capsule morphology / MGI
  • decreased testis weight / MGI
  • absent nasal septum / MGI
  • absent mandibular coronoid process / MGI
  • abnormal ciliary ganglion morphology / MGI
  • abnormal amnion morphology / MGI
  • abnormal incus morphology / MGI
  • holoprosencephaly / MGI
  • abnormal anterior eye segment morphology / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • abnormal extraocular muscle morphology / MGI
  • aniridia / MGI
  • absent pituitary gland / MGI
  • small cranium / MGI
  • embryo phenotype / MGI
  • craniofacial phenotype / MGI
  • reproductive system phenotype / MGI
  • vision/eye phenotype / MGI
  • retinal pigment epithelium hyperplasia / MGI
  • abnormal Meckel's cartilage morphology / MGI
  • abnormal horizontal cell morphology / MGI
  • abnormal retinal bipolar cell morphology / MGI
  • abnormal hindbrain development / MGI
  • decreased visual acuity / MGI
  • absent nasal placodes / MGI
  • absent optic vesicle / MGI
  • decreased retinal ganglion cell number / MGI
  • abnormal first pharyngeal arch morphology / MGI
  • abnormal gonadotroph morphology / MGI
  • decreased gonadotroph cell number / MGI
  • absent nasal capsule / MGI
  • decreased retinal cone cell number / MGI
  • thin retinal inner nuclear layer / MGI
  • thin retinal outer nuclear layer / MGI
  • abnormal olfactory epithelium morphology / MGI
  • absent choroid plexus / MGI
  • abnormal mesendoderm development / MGI
  • otocephaly / MGI
  • acephaly / MGI
  • abnormal pretectal region morphology / MGI
  • impaired somite development / MGI
  • absent tongue / MGI
  • mortality/aging / MGI
  • abnormal maxillary prominence morphology / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • abnormal cephalic neural fold morphology / MGI
  • absent heart / MGI
  • fused somites / MGI
  • absent foregut / MGI
  • absent midbrain / MGI
  • decreased midbrain size / MGI
  • midbrain hypoplasia / MGI
  • abnormal midbrain-hindbrain boundary morphology / MGI
  • embryonic-extraembryonic boundary constriction / MGI
  • absent forebrain / MGI
  • decreased forebrain size / MGI
  • rostral body truncation / MGI
  • absent cornea / MGI
  • absent prechordal mesoderm / MGI
  • absent metencephalon / MGI
  • absent diencephalon / MGI
  • abnormal primitive streak elongation / MGI
  • decreased embryonic neuroepithelium thickness / MGI
  • absent vomeronasal organ / MGI
  • absent embryonic telencephalon / MGI
  • abnormal visceral yolk sac endoderm morphology / MGI
  • abnormal visceral yolk sac mesenchyme morphology / MGI
  • absent orbitosphenoid bone / MGI
  • abnormal temporal bone tympanic part morphology / MGI
  • abnormal anterior head development / MGI

Literature references

  • The transcription factor Otx2 regulates choroid plexus development and function.;Johansson Pia A, Irmler Martin, Acampora Dario, Beckers Johannes, Simeone Antonio, Götz Magdalena, ;2013;Development (Cambridge, England);140;1055-66; 23364326

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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