- abnormal inner ear morphology / MGI
- absent semicircular canals / MGI
- abnormal cartilage morphology / MGI
- abnormal cranium morphology / MGI
- decreased brain size / MGI
- increased inferior colliculus size / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal third ventricle morphology / MGI
- abnormal cerebellar foliation / MGI
- abnormal midbrain morphology / MGI
- increased superior colliculus size / MGI
- abnormal trigeminal V mesencephalic nucleus morphology / MGI
- abnormal telencephalon development / MGI
- convulsive seizures / MGI
- nonconvulsive seizures / MGI
- small ovary / MGI
- abnormal ovarian folliculogenesis / MGI
- small testis / MGI
- arrest of spermatogenesis / MGI
- decreased body weight / MGI
- abnormal lens morphology / MGI
- abnormal iris morphology / MGI
- retina hyperplasia / MGI
- absent lacrimal glands / MGI
- circling / MGI
- postnatal growth retardation / MGI
- abnormal pituitary secretion / MGI
- seizures / MGI
- premature death / MGI
- abnormal eye morphology / MGI
- decreased brain weight / MGI
- abnormal seminiferous tubule morphology / MGI
- delayed fertility / MGI
- head shaking / MGI
- decreased circulating testosterone level / MGI
- decreased superior colliculus size / MGI
- absent lateral semicircular canal / MGI
- nervous system phenotype / MGI
- abnormal nervous system morphology / MGI
- abnormal orbitosphenoid bone morphology / MGI
- abnormal eye anterior chamber morphology / MGI
- hearing/vestibular/ear phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal vestibular saccule morphology / MGI
- abnormal utricle morphology / MGI
- small hippocampus / MGI
- absent Harderian gland / MGI
- decreased inferior colliculus size / MGI
- meteorism / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- increased cornea thickness / MGI
- decreased midbrain size / MGI
- absent ciliary process / MGI
- increased cerebellar foliation / MGI
STOCK Otx1tm6(cre/ERT)Asim/Cnrm
Status | Available to order |
EMMA ID | EM:05639 |
Citation information | RRID:IMSR_EM:05639 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | STOCK Otx1tm6(cre/ERT)Asim/Cnrm |
Alternative name | Otx1-CreER |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Otx1 |
Gene/Transgene symbol | Otx1 |
Information from provider
Provider | Antonio Simeone |
Provider affiliation | Ceinge Biotecnologie Avanzate |
Genetic information | The Otx1 allele is replaced with cre/ERT gene by homologous recombination. |
Phenotypic information | Homozygous mice showed spontaneous epileptic behaviour. Only faint (yet specific) activity of cre/ERT (as monitored by X-Gal staining of Otx1-cre/ERT embryos also carrying the R26R reporter allele). |
References | None available |
Homozygous fertile | not known |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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