STOCK Dlx5^tm1Levi/Cnrm

Status	Available to order
EMMA ID	EM:05637
International strain name	STOCK Dlx5^tm1Levi/Cnrm
Alternative name	Dlx5-LacZ
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Dlx5^tm1Levi
Gene/Transgene symbol	Dlx5

Information from provider

Provider	Antonio Simeone
Provider affiliation	Ceinge Biotecnologie Avanzate
Genetic information	Dlx5 is replaced with LacZ gene by homologous recombination.
Phenotypic information	Homozygous mutants die shortly after birth with a swollen abdomen. They present a complex phenotype characterised by craniofacial abnormalities affecting derivatives of the first four branchial arches, severe malformations of the vestibular organ, a delayed ossification of the roof of the skull and abnormal osteogenesis.
Breeding history	Targeted mutation was introduced in HM-1 ES cells. Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background.
References	Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.;Acampora D, Merlo G R, Paleari L, Zerega B, Postiglione M P, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, ;1999;Development (Cambridge, England);126;3795-809; 10433909
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Isolated split hand-split foot malformation / Orphanet_2440
Split hand-split foot-deafness syndrome / Orphanet_71271

MGI phenotypes (allele matching)

abnormal inner ear vestibule morphology / MGI
abnormal otic capsule morphology / MGI
delayed bone ossification / MGI
abnormal neurocranium morphology / MGI
abnormal basioccipital bone morphology / MGI
large anterior fontanelle / MGI
short mandible / MGI
short maxilla / MGI
abnormal cell proliferation / MGI
absent palatine bone horizontal plate / MGI
abnormal cranium morphology / MGI
short snout / MGI
exencephaly / MGI
distended abdomen / MGI
hypoactivity / MGI
abnormal suckling behavior / MGI
respiratory distress / MGI
abnormal thyroid cartilage morphology / MGI
abnormal semicircular canal morphology / MGI
abnormal hyoid bone morphology / MGI
decreased lateral semicircular canal size / MGI
absent posterior semicircular canal / MGI
absent superior semicircular canal / MGI
abnormal alisphenoid bone morphology / MGI
ectopic cartilage / MGI
abnormal craniofacial development / MGI
absent stapes / MGI
abnormal crista ampullaris morphology / MGI
abnormal crista ampullaris neuroepithelium morphology / MGI
abnormal pterygoid bone morphology / MGI
small nasal bone / MGI
short nasal bone / MGI
absent mandibular coronoid process / MGI
abnormal Meckel's cartilage morphology / MGI
decreased tympanic ring size / MGI
abnormal styloid process morphology / MGI
abnormal bone ossification / MGI
abnormal gonial bone morphology / MGI
abnormal osteoblast differentiation / MGI
meteorism / MGI
absent gastric milk in neonates / MGI
cleft secondary palate / MGI
decreased maxillary shelf size / MGI
abnormal hyoid bone greater horn morphology / MGI
abnormal hyoid bone lesser horn morphology / MGI
delayed cranial suture closure / MGI
neonatal lethality, complete penetrance / MGI
abnormal head development / MGI
short Meckel's cartilage / MGI
ectopic cranial bone / MGI
wide cranial sutures / MGI
Wormian bones / MGI
short styloid process / MGI
abnormal cochlea morphology / MGI
absent semicircular canals / MGI
decreased cochlear coiling / MGI
otic vesicle hypoplasia / MGI
abnormal vestibular saccular macula morphology / MGI
abnormal utricular macula morphology / MGI
enlarged utricle / MGI
abnormal vestibular saccule morphology / MGI
short endolymphatic duct / MGI

MGI phenotypes (gene matching)

abnormal malleus morphology / MGI
abnormal cochlea morphology / MGI
abnormal inner ear vestibule morphology / MGI
absent semicircular canals / MGI
abnormal otic capsule morphology / MGI
absent endolymphatic duct / MGI
abnormal middle ear morphology / MGI
delayed bone ossification / MGI
abnormal neurocranium morphology / MGI
abnormal interparietal bone morphology / MGI
abnormal basioccipital bone morphology / MGI
large anterior fontanelle / MGI
short mandible / MGI
short premaxilla / MGI
short maxilla / MGI
abnormal vomer bone morphology / MGI
abnormal nasal bone morphology / MGI
abnormal basisphenoid bone morphology / MGI
abnormal frontal bone morphology / MGI
abnormal parietal bone morphology / MGI
abnormal rib morphology / MGI
abnormal cell proliferation / MGI
absent palatine bone horizontal plate / MGI
abnormal cranium morphology / MGI
abnormal snout morphology / MGI
short snout / MGI
abnormal mouth morphology / MGI
abnormal jaw morphology / MGI
abnormal maxilla morphology / MGI
abnormal mandible morphology / MGI
abnormal hindlimb morphology / MGI
syndactyly / MGI
abnormal olfactory bulb morphology / MGI
abnormal brain development / MGI
exencephaly / MGI
open neural tube / MGI
abnormal sensory neuron innervation pattern / MGI
small trigeminal ganglion / MGI
decreased body size / MGI
distended abdomen / MGI
hypoactivity / MGI
abnormal suckling behavior / MGI
anencephaly / MGI
respiratory distress / MGI
perinatal lethality / MGI
abnormal vibrissa morphology / MGI
abnormal digit morphology / MGI
abnormal craniofacial bone morphology / MGI
no abnormal phenotype detected / MGI
abnormal outer ear morphology / MGI
abnormal nasal mucosa morphology / MGI
abnormal larynx morphology / MGI
abnormal thyroid cartilage morphology / MGI
abnormal semicircular canal morphology / MGI
brachydactyly / MGI
abnormal sexual interaction / MGI
micrognathia / MGI
abnormal molar morphology / MGI
small olfactory bulb / MGI
abnormal tooth mineralization / MGI
abnormal premaxilla morphology / MGI
abnormal pharyngeal arch morphology / MGI
abnormal hyoid bone morphology / MGI
abnormal metatarsal bone morphology / MGI
decreased cochlear coiling / MGI
decreased lateral semicircular canal size / MGI
absent posterior semicircular canal / MGI
absent superior semicircular canal / MGI
abnormal scala vestibuli morphology / MGI
abnormal alisphenoid bone morphology / MGI
abnormal GABAergic neuron morphology / MGI
abnormal axon extension / MGI
abnormal palate morphology / MGI
ectopic cartilage / MGI
abnormal molar crown morphology / MGI
abnormal craniofacial development / MGI
abnormal tongue muscle morphology / MGI
absent stapes / MGI
abnormal pterygoid muscle morphology / MGI
abnormal crista ampullaris morphology / MGI
abnormal rostral migratory stream morphology / MGI
otic vesicle hypoplasia / MGI
abnormal vestibular saccular macula morphology / MGI
abnormal utricular macula morphology / MGI
enlarged utricle / MGI
small interparietal bone / MGI
abnormal crista ampullaris neuroepithelium morphology / MGI
small parietal bone / MGI
abnormal temporal bone squamous part morphology / MGI
absent Meckel's cartilage / MGI
small supraoccipital bone / MGI
abnormal pterygoid process morphology / MGI
abnormal pterygoid bone morphology / MGI
small nasal bone / MGI
short nasal bone / MGI
turbinate hypoplasia / MGI
small maxilla / MGI
abnormal mandibular coronoid process morphology / MGI
abnormal mandibular condyloid process morphology / MGI
abnormal mandibular angle morphology / MGI
abnormal stapedial artery morphology / MGI
abnormal nasal capsule morphology / MGI
absent mandibular coronoid process / MGI
abnormal middle ear ossicle morphology / MGI
ectrodactyly / MGI
abnormal olfactory nerve morphology / MGI
abnormal occipital bone morphology / MGI
abnormal zygomatic bone morphology / MGI
abnormal lacrimal bone morphology / MGI
abnormal viscerocranium morphology / MGI
abnormal phalanx morphology / MGI
abnormal incisor morphology / MGI
abnormal Meckel's cartilage morphology / MGI
decreased tympanic ring size / MGI
abnormal external auditory canal morphology / MGI
abnormal vestibular saccule morphology / MGI
otic capsule hypoplasia / MGI
abnormal nasal pit morphology / MGI
abnormal first pharyngeal arch morphology / MGI
abnormal styloid process morphology / MGI
short endolymphatic duct / MGI
abnormal bone ossification / MGI
small malleus processus brevis / MGI
abnormal gonial bone morphology / MGI
abnormal osteoblast differentiation / MGI
abnormal olfactory epithelium morphology / MGI
meteorism / MGI
absent gastric milk in neonates / MGI
cleft secondary palate / MGI
cleft primary palate / MGI
decreased maxillary shelf size / MGI
abnormal frontonasal prominence morphology / MGI
abnormal lateral nasal prominence morphology / MGI
abnormal hyoid bone greater horn morphology / MGI
abnormal hyoid bone lesser horn morphology / MGI
abnormal stylohyoid ligament morphology / MGI
abnormal olfactory bulb granule cell morphology / MGI
abnormal olfactory bulb periglomerular cell morphology / MGI
abnormal mitral cell morphology / MGI
abnormal basicranium morphology / MGI
delayed cranial suture closure / MGI
abnormal mandibular prominence morphology / MGI
postnatal lethality, complete penetrance / MGI
neonatal lethality, complete penetrance / MGI
perinatal lethality, complete penetrance / MGI
prenatal lethality, incomplete penetrance / MGI
abnormal head development / MGI
absent vomeronasal organ / MGI
small vomeronasal organ / MGI
short Meckel's cartilage / MGI
absent olfactory epithelium / MGI
ectopic cranial bone / MGI
decreased bone mineralization / MGI
fused pharyngeal arches / MGI
wide cranial sutures / MGI
Wormian bones / MGI
small lacrimal bone / MGI
short lower incisors / MGI
short upper incisors / MGI
abnormal mylohyoid muscle morphology / MGI
abnormal epitympanic recess morphology / MGI
deviated nasal septum / MGI
short nasal septum / MGI
abnormal intrinsic tongue muscle morphology / MGI
frontonasal prominence hypoplasia / MGI
small vomer bone / MGI
lower jaw to upper jaw transformation / MGI
abnormal tegmen tympani morphology / MGI
short styloid process / MGI
small presphenoid bone / MGI
abnormal outer ear cartilage morphology / MGI
abnormal superior horn of thyroid cartilage morphology / MGI

Literature references

Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.;Acampora D, Merlo G R, Paleari L, Zerega B, Postiglione M P, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, ;1999;Development (Cambridge, England);126;3795-809; 10433909

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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STOCK Dlx5tm1Levi/Cnrm