IMPC phenotypes (gene matching)
STOCK Otptm1Asim/Cnrm
| Status | Available to order |
| EMMA ID | EM:05636 |
| Citation information | RRID:IMSR_EM:05636 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Otptm1Asim/Cnrm |
| Alternative name | Otp-LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Otptm1Asim |
| Gene/Transgene symbol | Otp |
Information from provider
| Provider | Antonio Simeone |
| Provider affiliation | Ceinge Biotecnologie Avanzate |
| Genetic information | Otp is replaced with LacZ gene by homologous recombination. |
| Phenotypic information | Homozygous brains at postnatal day (P1) showed evident abnormalities in the hypothalamus. |
| Breeding history | Targeted mutation was introduced in HM-1 ES cells. Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
- abnormal dopaminergic neuron morphology / MGI
MGI phenotypes (gene matching)
- decreased brain size / MGI
- abnormal third ventricle morphology / MGI
- abnormal diencephalon morphology / MGI
- abnormal hypothalamus morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal dopaminergic neuron morphology / MGI
- abnormal neurohypophysis morphology / MGI
- abnormal hypothalamus physiology / MGI
- abnormal paraventricular hypothalamic nucleus morphology / MGI
- abnormal supraoptic nucleus morphology / MGI
- abnormal neurohypophysis median eminence morphology / MGI
- postnatal lethality, complete penetrance / MGI
Literature references
- Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene.;Acampora D, Postiglione M P, Avantaggiato V, Di Bonito M, Vaccarino F M, Michaud J, Simeone A, ;1999;Genes & development;13;2787-800; 10557207