STOCK Otptm1Asim/Cnrm
Status | Available to order |
EMMA ID | EM:05636 |
International strain name | STOCK Otptm1Asim/Cnrm |
Alternative name | Otp-LacZ |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Otptm1Asim |
Gene/Transgene symbol | Otp |
Information from provider
Provider | Antonio Simeone |
Provider affiliation | Ceinge Biotecnologie Avanzate |
Genetic information | Otp is replaced with LacZ gene by homologous recombination. |
Phenotypic information | Homozygous brains at postnatal day (P1) showed evident abnormalities in the hypothalamus. |
Breeding history | Targeted mutation was introduced in HM-1 ES cells. Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- abnormal dopaminergic neuron morphology / MGI
MGI phenotypes (gene matching)
- decreased brain size / MGI
- abnormal third ventricle morphology / MGI
- abnormal diencephalon morphology / MGI
- abnormal hypothalamus morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal dopaminergic neuron morphology / MGI
- abnormal neurohypophysis morphology / MGI
- abnormal hypothalamus physiology / MGI
- abnormal paraventricular hypothalamic nucleus morphology / MGI
- abnormal supraoptic nucleus morphology / MGI
- abnormal neurohypophysis median eminence morphology / MGI
- postnatal lethality, complete penetrance / MGI
Literature references
- Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene.;Acampora D, Postiglione M P, Avantaggiato V, Di Bonito M, Vaccarino F M, Michaud J, Simeone A, ;1999;Genes & development;13;2787-800; 10557207
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