MGI phenotypes (allele matching)
- immune system phenotype / MGI
B6.Cg-Ncr1tm2.1Viv/Orl
| Status | Available to order |
| EMMA ID | EM:05627 |
| Citation information | RRID:IMSR_EM:05627 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Ncr1tm2.1Viv/Orl |
| Alternative name | NKp46-LAPTAG-eGFP KI (NKLT KI) |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Ncr1tm2.1Viv |
| Gene/Transgene symbol | Ncr1 |
Information from provider
| Provider | Eric Vivier |
| Provider affiliation | CNRS-INSERM-UNIVERSITE DE LA MEDITERRANNEE-U631, Centre D'immunologie Marseille-Luminy |
| Genetic information | A cassette encoding eGFP and a localization and affinity purification tag (LAP-TAG) sequence was inserted in frame to the end of the Ncr1 gene (NKp46). This construct results in a NKp46-enhanced green fluorescent protein (eGFP)-LAPTAG fusion protein which replaced the endogenous NKp46 protein. All the Ncr1+ (NKp46+) NK cells expressed eGFP. |
| Phenotypic information | There is no significant phenotype. |
| Breeding history | These mice are on a C57BL/6 background. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
- decreased susceptibility to viral infection / MGI
- increased susceptibility to bacterial infection / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- increased NK cell number / MGI
- decreased NK cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased susceptibility to viral infection induced morbidity/mortality / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- decreased CD8-positive, alpha-beta memory T cell number / MGI
Literature references
- Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance.;Guia Sophie, Jaeger Baptiste N, Piatek Stefan, Mailfert Sébastien, Trombik Tomasz, Fenis Aurore, Chevrier Nicolas, Walzer Thierry, Kerdiles Yann M, Marguet Didier, Vivier Eric, Ugolini Sophie, ;2011;Science signaling;4;ra21; 21467299