MGI phenotypes (allele matching)
- immune system phenotype / MGI
B6.Cg-Ncr1tm2.1Viv/Orl
| Status | Available to order |
| EMMA ID | EM:05627 |
| International strain name | B6.Cg-Ncr1tm2.1Viv/Orl |
| Alternative name | NKp46-LAPTAG-eGFP KI (NKLT KI) |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Ncr1tm2.1Viv |
| Gene/Transgene symbol | Ncr1 |
Information from provider
| Provider | Eric Vivier |
| Provider affiliation | CNRS-INSERM-UNIVERSITE DE LA MEDITERRANNEE-U631, Centre D'immunologie Marseille-Luminy |
| Genetic information | A cassette encoding eGFP and a localization and affinity purification tag (LAP-TAG) sequence was inserted in frame to the end of the Ncr1 gene (NKp46). This construct results in a NKp46-enhanced green fluorescent protein (eGFP)-LAPTAG fusion protein which replaced the endogenous NKp46 protein. All the Ncr1+ (NKp46+) NK cells expressed eGFP. |
| Phenotypic information | There is no significant phenotype. |
| Breeding history | These mice are on a C57BL/6 background. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
- decreased susceptibility to viral infection / MGI
- increased susceptibility to bacterial infection / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- increased NK cell number / MGI
- decreased NK cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased susceptibility to viral infection induced morbidity/mortality / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- decreased CD8-positive, alpha-beta memory T cell number / MGI
Literature references
- Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance.;Guia Sophie, Jaeger Baptiste N, Piatek Stefan, Mailfert Sébastien, Trombik Tomasz, Fenis Aurore, Chevrier Nicolas, Walzer Thierry, Kerdiles Yann M, Marguet Didier, Vivier Eric, Ugolini Sophie, ;2011;Science signaling;4;ra21; 21467299