MGI phenotypes (allele matching)
B6.Cg-Ncr1tm1.1(icre)Viv/Orl
| Status | Available to order |
| EMMA ID | EM:05625 |
| Citation information | RRID:IMSR_EM:05625 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Ncr1tm1.1(icre)Viv/Orl |
| Alternative name | NKp46iCre KI |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Ncr1tm1.1(icre)Viv |
| Gene/Transgene symbol | Ncr1 |
Information from provider
| Provider | Eric Vivier |
| Provider affiliation | CNRS-INSERM-UNIVERSITE DE LA MEDITERRANNEE-U631, Centre D'immunologie Marseille-Luminy |
| Genetic information | A cassette encoding IRES and cre recombinase was inserted just after the STOP sequence of the Ncr1 gene into the 3-prime UTR non-coding sequence. All the Ncr1+ (NKp46+) NK cells express cre recombinase. |
| Phenotypic information | There is no significant phenotype. |
| Breeding history | These mice are on a C57BL/6 background. The mice were crossed with a flp-expressing transgenic mouse to remove the neomycin selection cassette, then the progeny was crossed with a C57BL/6 mice to remove the flp transgene. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
- decreased susceptibility to viral infection / MGI
- increased susceptibility to bacterial infection / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- increased NK cell number / MGI
- decreased NK cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased susceptibility to viral infection induced morbidity/mortality / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- decreased CD8-positive, alpha-beta memory T cell number / MGI
Literature references
- Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor.;Narni-Mancinelli Emilie, Chaix Julie, Fenis Aurore, Kerdiles Yann M, Yessaad Nadia, Reynders Ana, Gregoire Claude, Luche Herve, Ugolini Sophie, Tomasello Elena, Walzer Thierry, Vivier Eric, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;18324-9; 22021440
- Functional visualization of NK cell-mediated killing of metastatic single tumor cells.;Ichise Hiroshi, Tsukamoto Shoko, Hirashima Tsuyoshi, Konishi Yoshinobu, Oki Choji, Tsukiji Shinya, Iwano Satoshi, Miyawaki Atsushi, Sumiyama Kenta, Terai Kenta, Matsuda Michiyuki, ;2022;eLife;11;101-106; 35113018
- TIM-3 restrains anti-tumour immunity by regulating inflammasome activation.;Dixon Karen O, Tabaka Marcin, Schramm Markus A, Xiao Sheng, Tang Ruihan, Dionne Danielle, Anderson Ana C, Rozenblatt-Rosen Orit, Regev Aviv, Kuchroo Vijay K, ;2021;Nature;595;; 34108686