MGI phenotypes (allele matching)
B6.Cg-Ncr1tm1.1(icre)Viv/Orl
| Status | Available to order |
| EMMA ID | EM:05625 |
| International strain name | B6.Cg-Ncr1tm1.1(icre)Viv/Orl |
| Alternative name | NKp46iCre KI |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Ncr1tm1.1(icre)Viv |
| Gene/Transgene symbol | Ncr1 |
Information from provider
| Provider | Eric Vivier |
| Provider affiliation | CNRS-INSERM-UNIVERSITE DE LA MEDITERRANNEE-U631, Centre D'immunologie Marseille-Luminy |
| Genetic information | A cassette encoding IRES and cre recombinase was inserted just after the STOP sequence of the Ncr1 gene into the 3-prime UTR non-coding sequence. All the Ncr1+ (NKp46+) NK cells express cre recombinase. |
| Phenotypic information | There is no significant phenotype. |
| Breeding history | These mice are on a C57BL/6 background. The mice were crossed with a flp-expressing transgenic mouse to remove the neomycin selection cassette, then the progeny was crossed with a C57BL/6 mice to remove the flp transgene. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
- decreased susceptibility to viral infection / MGI
- increased susceptibility to bacterial infection / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- increased NK cell number / MGI
- decreased NK cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased susceptibility to viral infection induced morbidity/mortality / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- decreased CD8-positive, alpha-beta memory T cell number / MGI
Literature references
- Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor.;Narni-Mancinelli Emilie, Chaix Julie, Fenis Aurore, Kerdiles Yann M, Yessaad Nadia, Reynders Ana, Gregoire Claude, Luche Herve, Ugolini Sophie, Tomasello Elena, Walzer Thierry, Vivier Eric, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;18324-9; 22021440
- Functional visualization of NK cell-mediated killing of metastatic single tumor cells.;Ichise Hiroshi, Tsukamoto Shoko, Hirashima Tsuyoshi, Konishi Yoshinobu, Oki Choji, Tsukiji Shinya, Iwano Satoshi, Miyawaki Atsushi, Sumiyama Kenta, Terai Kenta, Matsuda Michiyuki, ;2022;eLife;11;101-106; 35113018
- TIM-3 restrains anti-tumour immunity by regulating inflammasome activation.;Dixon Karen O, Tabaka Marcin, Schramm Markus A, Xiao Sheng, Tang Ruihan, Dionne Danielle, Anderson Ana C, Rozenblatt-Rosen Orit, Regev Aviv, Kuchroo Vijay K, ;2021;Nature;595;; 34108686