STOCK Otx1tm4(cre)Asim/Cnrm

Status

Available to order

EMMA IDEM:05622
Citation informationRRID:IMSR_EM:05622 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Otx1tm4(cre)Asim/Cnrm
Alternative nameOtx1-Cre
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolOtx1tm4(cre)Asim
Gene/Transgene symbolOtx1

Information from provider

ProviderAntonio Simeone
Provider affiliationCeinge Biotecnologie Avanzate
Genetic informationOtx1 exon 1 and 2 are replaced with cre recombinase gene by homologous recombination.
Phenotypic informationHomozygous mice showed spontaneous epileptic behaviour and reduction of brain weight by about 25% and females lack of parental care.
Breeding historyMice were always maintained in a mixed C57BL/6 and DBA/2 genetic background.
References
  • Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.;Puelles Eduardo, Acampora Dario, Lacroix Emmanuel, Signore Massimo, Annino Alessandro, Tuorto Francesca, Filosa Stefania, Corte Giorgio, Wurst Wolfgang, Ang Siew-Lan, Simeone Antonio, ;2003;Nature neuroscience;6;453-60; 12652306
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal inner ear morphology / MGI
  • absent semicircular canals / MGI
  • abnormal cartilage morphology / MGI
  • abnormal cranium morphology / MGI
  • decreased brain size / MGI
  • increased inferior colliculus size / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal third ventricle morphology / MGI
  • abnormal cerebellar foliation / MGI
  • abnormal midbrain morphology / MGI
  • increased superior colliculus size / MGI
  • abnormal trigeminal V mesencephalic nucleus morphology / MGI
  • abnormal telencephalon development / MGI
  • convulsive seizures / MGI
  • nonconvulsive seizures / MGI
  • small ovary / MGI
  • abnormal ovarian folliculogenesis / MGI
  • small testis / MGI
  • arrest of spermatogenesis / MGI
  • decreased body weight / MGI
  • abnormal lens morphology / MGI
  • abnormal iris morphology / MGI
  • retina hyperplasia / MGI
  • absent lacrimal glands / MGI
  • circling / MGI
  • postnatal growth retardation / MGI
  • abnormal pituitary secretion / MGI
  • seizures / MGI
  • premature death / MGI
  • abnormal eye morphology / MGI
  • decreased brain weight / MGI
  • abnormal seminiferous tubule morphology / MGI
  • delayed fertility / MGI
  • head shaking / MGI
  • decreased circulating testosterone level / MGI
  • decreased superior colliculus size / MGI
  • absent lateral semicircular canal / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system morphology / MGI
  • abnormal orbitosphenoid bone morphology / MGI
  • abnormal eye anterior chamber morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal vestibular saccule morphology / MGI
  • abnormal utricle morphology / MGI
  • small hippocampus / MGI
  • absent Harderian gland / MGI
  • decreased inferior colliculus size / MGI
  • meteorism / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • increased cornea thickness / MGI
  • decreased midbrain size / MGI
  • absent ciliary process / MGI
  • increased cerebellar foliation / MGI

Literature references

  • Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.;Puelles Eduardo, Acampora Dario, Lacroix Emmanuel, Signore Massimo, Annino Alessandro, Tuorto Francesca, Filosa Stefania, Corte Giorgio, Wurst Wolfgang, Ang Siew-Lan, Simeone Antonio, ;2003;Nature neuroscience;6;453-60; 12652306

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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