STOCK Otx1tm1Asim/Cnrm

Status

Available to order

EMMA IDEM:05620
International strain nameSTOCK Otx1tm1Asim/Cnrm
Alternative nameOtx1-LacZ
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolOtx1tm1Asim
Gene/Transgene symbolOtx1

Information from provider

ProviderAntonio Simeone
Provider affiliationCeinge Biotecnologie Avanzate
Additional ownerPhilippe Brulet, Unité d'Embryologie Moléculaire, Centre National de la Recherche Scientifique (CNRS), Institut Pasteur, Paris, France
Genetic informationOtx1 exon 1 and 2 are replaced with lacZ gene by homologous recombination.
Phenotypic informationHomozygous mice show spontaneous epileptic behaviour and adult brain is reduced in weight by about 25%; females lack parental care.
Breeding historyTargeted mutation was introduced in HM-1 ES cells. Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background.
References
  • Epilepsy and brain abnormalities in mice lacking the Otx1 gene.;Acampora D, Mazan S, Avantaggiato V, Barone P, Tuorto F, Lallemand Y, Brûlet P, Simeone A, ;1996;Nature genetics;14;218-22; 8841200
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • absent semicircular canals / MGI
  • increased inferior colliculus size / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal cerebellar foliation / MGI
  • abnormal midbrain morphology / MGI
  • increased superior colliculus size / MGI
  • convulsive seizures / MGI
  • nonconvulsive seizures / MGI
  • small ovary / MGI
  • abnormal ovarian folliculogenesis / MGI
  • small testis / MGI
  • arrest of spermatogenesis / MGI
  • decreased body weight / MGI
  • abnormal iris morphology / MGI
  • absent lacrimal glands / MGI
  • postnatal growth retardation / MGI
  • abnormal pituitary secretion / MGI
  • premature death / MGI
  • decreased brain weight / MGI
  • abnormal seminiferous tubule morphology / MGI
  • delayed fertility / MGI
  • decreased circulating testosterone level / MGI
  • absent Harderian gland / MGI
  • abnormal inner ear morphology / MGI
  • decreased brain size / MGI
  • abnormal telencephalon development / MGI
  • seizures / MGI
  • absent lateral semicircular canal / MGI
  • absent ciliary process / MGI
MGI phenotypes (gene matching)
  • abnormal inner ear morphology / MGI
  • absent semicircular canals / MGI
  • abnormal cartilage morphology / MGI
  • abnormal cranium morphology / MGI
  • decreased brain size / MGI
  • increased inferior colliculus size / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal third ventricle morphology / MGI
  • abnormal cerebellar foliation / MGI
  • abnormal midbrain morphology / MGI
  • increased superior colliculus size / MGI
  • abnormal trigeminal V mesencephalic nucleus morphology / MGI
  • abnormal telencephalon development / MGI
  • convulsive seizures / MGI
  • nonconvulsive seizures / MGI
  • small ovary / MGI
  • abnormal ovarian folliculogenesis / MGI
  • small testis / MGI
  • arrest of spermatogenesis / MGI
  • decreased body weight / MGI
  • abnormal lens morphology / MGI
  • abnormal iris morphology / MGI
  • retina hyperplasia / MGI
  • absent lacrimal glands / MGI
  • circling / MGI
  • postnatal growth retardation / MGI
  • abnormal pituitary secretion / MGI
  • seizures / MGI
  • premature death / MGI
  • abnormal eye morphology / MGI
  • decreased brain weight / MGI
  • abnormal seminiferous tubule morphology / MGI
  • delayed fertility / MGI
  • head shaking / MGI
  • decreased circulating testosterone level / MGI
  • decreased superior colliculus size / MGI
  • absent lateral semicircular canal / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system morphology / MGI
  • abnormal orbitosphenoid bone morphology / MGI
  • abnormal eye anterior chamber morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal vestibular saccule morphology / MGI
  • abnormal utricle morphology / MGI
  • small hippocampus / MGI
  • absent Harderian gland / MGI
  • decreased inferior colliculus size / MGI
  • meteorism / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • increased cornea thickness / MGI
  • decreased midbrain size / MGI
  • absent ciliary process / MGI
  • increased cerebellar foliation / MGI

Literature references

  • Epilepsy and brain abnormalities in mice lacking the Otx1 gene.;Acampora D, Mazan S, Avantaggiato V, Barone P, Tuorto F, Lallemand Y, Brûlet P, Simeone A, ;1996;Nature genetics;14;218-22; 8841200

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
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