| Status | Available to order |
| EMMA ID | EM:05597 |
| Citation information | RRID:IMSR_EM:05597 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Ifnar1tm1Agt Tg(Hmgcr-SLAMF1)1Hrvt/Orl |
| Alternative name | SLAMxIFNAR KO |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Hmgcr-SLAMF1)1Hrvt, Ifnar1tm1Agt |
| Gene/Transgene symbol | Tg(Hmgcr-SLAMF1)1Hrvt, Ifnar1 |
| Provider | Branka Horvat |
| Provider affiliation | INSERM |
| Genetic information | Mice are transgenic for the human receptor for measles virus CD150 (SLAM), crossed to the background of interferon alpha/beta receptor (Ifnar1) knock-out. |
| Phenotypic information | Mice are highly susceptible to the intranasal measles virus infection and allow testing of the efficiency of mealses vaccines and anti-viral treatment. |
| Breeding history | SLAM transgenic mice were crossed initially to the C57BL/6 background during 10 generations. This line was then crossed in the interferon receptor alpha/beta (Ifnar1) deficient background. Embryos and sperm have been obtained and frozen at PBES (Plateau de Biologie Expérimentale de la Souris Ecole Normale Superieure de Lyon) in Lyon. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | yes |
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
| Breeding at archiving centre | Males and females are homozygous knock-out for Ifnar1-tm1Agt; males and females are heterozygous for the Tg(Hmgcr-SLAMF1)1Hrvt (SLAM) transgene. |
