B6.Cg-Ifnar1^tm1Agt Tg(Hmgcr-SLAMF1)1Hrvt/Orl

Status	Available to order
EMMA ID	EM:05597
International strain name	B6.Cg-Ifnar1^tm1Agt Tg(Hmgcr-SLAMF1)1Hrvt/Orl
Alternative name	SLAMxIFNAR KO
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Hmgcr-SLAMF1)1Hrvt, Ifnar1^tm1Agt
Gene/Transgene symbol	Tg(Hmgcr-SLAMF1)1Hrvt, Ifnar1

Information from provider

Provider	Branka Horvat
Provider affiliation	INSERM
Genetic information	Mice are transgenic for the human receptor for measles virus CD150 (SLAM), crossed to the background of interferon alpha/beta receptor (Ifnar1) knock-out.
Phenotypic information	Mice are highly susceptible to the intranasal measles virus infection and allow testing of the efficiency of mealses vaccines and anti-viral treatment.
Breeding history	SLAM transgenic mice were crossed initially to the C57BL/6 background during 10 generations. This line was then crossed in the interferon receptor alpha/beta (Ifnar1) deficient background. Embryos and sperm have been obtained and frozen at PBES (Plateau de Biologie Expérimentale de la Souris Ecole Normale Superieure de Lyon) in Lyon.
References	Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis.;Sellin Caroline I, Jégou Jean-François, Renneson Joëlle, Druelle Johan, Wild T Fabian, Marie Julien C, Horvat Branka, ;2009;PloS one;4;e4948; 19319188 High pathogenicity of wild-type measles virus infection in CD150 (SLAM) transgenic mice.;Sellin Caroline I, Davoust Nathalie, Guillaume Vanessa, Baas Dominique, Belin Marie-Françoise, Buckland Robin, Wild T Fabian, Horvat Branka, ;2006;Journal of virology;80;6420-9; 16775330
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	yes
Immunocompromised	yes

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	homozygous C57BL/6J, wild-type C57BL/6J
Breeding at archiving centre	Males and females are homozygous knock-out for Ifnar1-tm1Agt; males and females are heterozygous for the Tg(Hmgcr-SLAMF1)1Hrvt (SLAM) transgene.

Disease and phenotype information

IMPC phenotypes (gene matching)

improved glucose tolerance / IMPC
decreased circulating fructosamine level / IMPC
decreased monocyte cell number / IMPC
decreased KLRG1-positive NK cell number / IMPC
increased circulating creatinine level / IMPC
abnormal vibrissa morphology / IMPC
increased bone mineral content / IMPC
increased circulating amylase level / IMPC

MGI phenotypes (allele matching)

decreased bone mineral density / MGI
increased tumor growth/size / MGI
abnormal osteoclast morphology / MGI
abnormal response to infection / MGI
impaired natural killer cell mediated cytotoxicity / MGI
decreased tumor necrosis factor secretion / MGI
decreased interferon-alpha secretion / MGI
decreased interferon-beta secretion / MGI
decreased interleukin-6 secretion / MGI
increased susceptibility to bacterial infection induced morbidity/mortality / MGI
abnormal inflammatory response / MGI
abnormal dendritic cell physiology / MGI
increased susceptibility to viral infection / MGI
abnormal immunoglobulin level / MGI
abnormal cytokine secretion / MGI
corneal vascularization / MGI
increased susceptibility to viral infection induced morbidity/mortality / MGI
abnormal NK cell physiology / MGI
altered susceptibility to infection / MGI
immune system phenotype / MGI
abnormal CD8-positive, alpha-beta T cell physiology / MGI
abnormal interferon-gamma secretion / MGI
increased circulating interleukin-12 level / MGI

MGI phenotypes (gene matching)

decreased bone mineral density / MGI
increased leukocyte cell number / MGI
altered susceptibility to infection / MGI
abnormal inflammatory response / MGI
increased incidence of induced tumors / MGI
abnormal dendritic cell physiology / MGI
increased susceptibility to viral infection / MGI
abnormal macrophage physiology / MGI
abnormal immunoglobulin level / MGI
abnormal cytokine secretion / MGI
no phenotypic analysis / MGI
increased tumor growth/size / MGI
abnormal CD8-positive, alpha-beta T cell physiology / MGI
increased incidence of tumors by chemical induction / MGI
abnormal osteoclast morphology / MGI
abnormal response to infection / MGI
impaired natural killer cell mediated cytotoxicity / MGI
immune system phenotype / MGI
corneal vascularization / MGI
abnormal enzyme/coenzyme activity / MGI
decreased NK cell number / MGI
abnormal interferon-gamma secretion / MGI
decreased tumor necrosis factor secretion / MGI
decreased interferon-alpha secretion / MGI
decreased interferon-beta secretion / MGI
increased circulating interleukin-12 level / MGI
decreased interleukin-6 secretion / MGI
increased susceptibility to bacterial infection induced morbidity/mortality / MGI
increased susceptibility to viral infection induced morbidity/mortality / MGI
abnormal NK cell physiology / MGI

Literature references

Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis.;Sellin Caroline I, Jégou Jean-François, Renneson Joëlle, Druelle Johan, Wild T Fabian, Marie Julien C, Horvat Branka, ;2009;PloS one;4;e4948; 19319188
High pathogenicity of wild-type measles virus infection in CD150 (SLAM) transgenic mice.;Sellin Caroline I, Davoust Nathalie, Guillaume Vanessa, Baas Dominique, Belin Marie-Françoise, Buckland Robin, Wild T Fabian, Horvat Branka, ;2006;Journal of virology;80;6420-9; 16775330

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6.Cg-Ifnar1tm1Agt Tg(Hmgcr-SLAMF1)1Hrvt/Orl