IMPC phenotypes (gene matching)
B6;129P2-Tiam1tm1Jgc/Cnbc
| Status | Available to order |
| EMMA ID | EM:05563 |
| International strain name | B6;129P2-Tiam1tm1Jgc/Cnbc |
| Alternative name | C57BL/6-Tiam1 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tiam1tm1Jgc |
| Gene/Transgene symbol | Tiam1 |
Information from provider
| Provider | John Collard |
| Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
| Genetic information | Mice that are deficient for the Rac activator Tiam1. |
| Phenotypic information | Mice do not have an obvious phenotype and are fertile. However tumorigenicity is highly affected. In general tumor formation and growth is reduced but metastasis is enhanced. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased cell proliferation / MGI
- abnormal forebrain morphology / MGI
- abnormal diencephalon morphology / MGI
- exencephaly / MGI
- abnormal apoptosis / MGI
- anencephaly / MGI
- increased malignant tumor incidence / MGI
- increased squamous cell carcinoma incidence / MGI
- decreased incidence of tumors by chemical induction / MGI
Literature references
- Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.;Malliri Angeliki, van der Kammen Rob A, Clark Kristopher, van der Valk Maarten, Michiels Frits, Collard John G, ;2002;Nature;417;867-71; 12075356
- The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.;Malliri Angeliki, Rygiel Tomasz P, van der Kammen Rob A, Song Ji-Ying, Engers Rainer, Hurlstone Adam F L, Clevers Hans, Collard John G, ;2006;The Journal of biological chemistry;281;543-8; 16249175
- Prognostic relevance of Tiam1 protein expression in prostate carcinomas.;Engers R, Mueller M, Walter A, Collard J G, Willers R, Gabbert H E, ;2006;British journal of cancer;95;1081-6; 17003780
- Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice.;Strumane K, Rygiel T, van der Valk M, Collard J G, ;2009;Journal of cancer research and clinical oncology;135;69-80; 18592271
- Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency.;Strumane Kristin, Song Ji-Ying, Baas Inge, Collard John G, ;2008;Leukemia research;32;113-20; 17521720