MGI phenotypes (gene matching)
- embryonic lethality, complete penetrance / MGI
B6.129S7-Dp(17Nfkbil1-Or2h1)1Cogr/Cnrm
| Status | Available to order |
| EMMA ID | EM:05559 |
| Citation information | RRID:IMSR_EM:05559 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S7-Dp(17Nfkbil1-Or2h1)1Cogr/Cnrm |
| Alternative name | Dp(MHC-I) |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Dp(17Nfkbil1-Or2h1)1Cogr |
| Gene/Transgene symbol | Dp(17Nfkbil1-Or2h1)1Cogr |
Information from provider
| Provider | Cornelius Gross |
| Provider affiliation | Mouse Biology Unit, European Molecular Biology Laboratory |
| Genetic information | Proximal loxP site was targeted by MICER clone MHPP188d21 located at 35.3 Mb upstream of Nfkbil1 gene, distal MICER clone is MHPN390j16 and located at 37.25 Mb downstream of the Olfr91. Embryonic stem cells that were double-targeted in trans were subjected to transient Cre expression and underwent recombination to produce a reciprocal duplication of the Nfkbil1-Olfr91 interval. Dp17(MHC-1) is encompassing 1.9 Mb of MHC classical class I (Nfkbil1-Olfr91) region on mouse chromosome 17 and is syntenic to human chromosome 6p22.1 and 6p21.33 interval. |
| Phenotypic information | None |
| Breeding history | ES cells were injected into C57BL/6 blastocysts. Male chimerae were crossed to C57BL/6J mice for six generations. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus.;Ermakova Olga, Salimova Ekaterina, Piszczek Lukasz, Gross Cornelius, ;2012;Mammalian genome : official journal of the International Mammalian Genome Society;23;443-53; 22772436