| Status | Available to order |
| EMMA ID | EM:05544 |
| International strain name | CBA.129S(B6)-Tectatm2Gpr/H |
| Alternative name | CBA/Tectatm2Gpr |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Tectatm2Gpr |
| Gene/Transgene symbol | Tecta |
| Provider | Guy Richardson |
| Provider affiliation | Ancillary Unit, University of Sussex |
| Genetic information | A Hit-and-Run vector was prepared from a 129/SvEv cosmid to introduce the Y1870C point mutation into exon 18 of Tecta. |
| Phenotypic information | Heterozygous mice suffer hearing loss and have tectorial membranes with a thin limbal attachment zone, missing marginal band and Hensen's stripe and large holes in the main body of the matrix. The subtectorial space above the inner hair cells is also enlarged. Heterozygous mice show elevated neural thresholds, broadened neural tuning and a decrease in sensitivity at the tip of the neural tuning curve. Many mouse strains do not behave well under anaesthesia and/or suffer from age related hearing loss, especially in the high-frequency basal end of the cochlea. Neither the C57BL/6 nor the CBA strain mice are very suitable for recording intra- and extracellular potentials from cochlear hair cells under anaesthesia, and the C57BL/6 strain suffers from age related hearing loss (due to a mutation in the Cdh23 gene at the ahl (age-related hearing loss 1) locus. Therefore, if the scientists who work with these mice want to do physiology on anaesthetised animals, it is proposed that they order both strains and use (CBA x C57BL/6)F1 hybrids for experimentation. |
| Breeding history | Original 129/SvEv:C57BL/6J mice have been outbred to CBA to F26. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous CBA |
| Breeding at archiving centre | Males were archived upon arrival. No breeding was performed at the archiving centre. |
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
