IMPC phenotypes (allele matching)
C57BL/6NTac-Nxntm1a(EUCOMM)Wtsi/Ieg
| Status | Available to order |
| EMMA ID | EM:05537 |
| International strain name | C57BL/6NTac-Nxntm1a(EUCOMM)Wtsi/Ieg |
| Alternative name | EPD0045_1_B11 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Nxntm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Nxn |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0045_1_B11. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTacUSA, wild-type C57BL/6NTacUSA |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive Robinow syndrome / Orphanet_1507
IMPC phenotypes (gene matching)
- abnormal embryo size / IMPC
- cleft palate / IMPC
- unresponsive to tactile stimuli / IMPC
- abnormal facial morphology / IMPC
- abnormal craniofacial morphology / IMPC
- facial cleft / IMPC
- increased circulating alkaline phosphatase level / IMPC
- decreased cardiac muscle contractility / IMPC
- increased grip strength / IMPC
- abnormal head size / IMPC
- increased mean corpuscular hemoglobin concentration / IMPC
- preweaning lethality, complete penetrance / IMPC
- abnormal head shape / IMPC
- small adrenal glands / IMPC
- decreased locomotor activity / IMPC
- abnormal freezing behavior / IMPC
- decreased body length / IMPC
- abnormal eyelid morphology / IMPC
- abnormal digit morphology / IMPC
- abnormal optic disk morphology / IMPC
- abnormal locomotor behavior / IMPC
- increased circulating bilirubin level / IMPC
- microcephaly / IMPC
- short tibia / IMPC
- abnormal mammary gland morphology / IMPC
- anophthalmia / IMPC
- abnormal retina blood vessel morphology / IMPC
- irregularly shaped pupil / IMPC
- syndactyly / IMPC
- abnormal cranium morphology / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
- decreased exploration in new environment / IMPC
- abnormal behavior / IMPC
- no spontaneous movement / IMPC
- increased fasting circulating glucose level / IMPC
- abnormal snout morphology / IMPC
- increased circulating HDL cholesterol level / IMPC
- increased circulating triglyceride level / IMPC
MGI phenotypes (gene matching)
- cleft palate / MGI
- abnormal sternum morphology / MGI
- double outlet right ventricle / MGI
- enlarged liver sinusoidal spaces / MGI
- persistent truncus arteriosis / MGI
- abnormal Mullerian duct morphology / MGI
- decreased fetal size / MGI
- small frontal bone / MGI
- absent stapedial artery / MGI
- split xiphoid process / MGI
- increased osteoblast cell number / MGI
- abnormal cell physiology / MGI
- ventricular septal defect / MGI
- atrioventricular septal defect / MGI
- perimembraneous ventricular septal defect / MGI
- herniated liver / MGI
- perinatal lethality, complete penetrance / MGI
- decreased intestine length / MGI
- abnormal vitelline vein topology / MGI