C57BL/6N-Gpsm2tm1a(EUCOMM)Wtsi/Ieg
Status | Available to order |
EMMA ID | EM:05535 |
International strain name | C57BL/6N-Gpsm2tm1a(EUCOMM)Wtsi/Ieg |
Alternative name | EPD0519_5_G12 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Gpsm2tm1a(EUCOMM)Wtsi |
Gene/Transgene symbol | Gpsm2 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0519_5_G12. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | heterozygous C57BL/6NTacUSA, wild-type C57BL/6NTacUSA |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
- Chudley-McCullough syndrome / Orphanet_314597
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- deafness / MGI
- abnormal cochlear hair cell morphology / MGI
- abnormal neuron specification / MGI
- no phenotypic analysis / MGI
- nervous system phenotype / MGI
- abnormal orientation of outer hair cell stereociliary bundles / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- abnormal outer hair cell stereociliary bundle morphology / MGI
- abnormal inner hair cell stereociliary bundle morphology / MGI
- short inner hair cell stereocilia / MGI
- abnormal cell differentiation / MGI
- absent pinna reflex / MGI
- absent startle reflex / MGI
- abnormal kinocilium morphology / MGI
- increased or absent threshold for auditory brainstem response / MGI
- abnormal cell cytoskeleton morphology / MGI
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