C57BL/6NTac-Pik3cb^{tm1a(EUCOMM)Wtsi}/WtsiOulu

Status	Available to order
EMMA ID	EM:05526
Citation information	RRID:IMSR_EM:05526 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Pik3cb^{tm1a(EUCOMM)Wtsi}/WtsiOulu
Alternative name	EPD0051_3_E05
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Pik3cb^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Pik3cb
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from EUCOMM ES clone EPD0051_3_E05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Archiving centre	University of Oulu, Oulu, Finland

IMPC phenotypes (allele matching)

IMPC phenotypes (gene matching)

MGI phenotypes (allele matching)

MGI phenotypes (gene matching)

decreased body weight / MGI
weight loss / MGI
decreased embryo size / MGI
postnatal growth retardation / MGI
decreased circulating triglyceride level / MGI
increased insulin secretion / MGI
abnormal gluconeogenesis / MGI
decreased lumbar vertebrae number / MGI
decreased circulating cholesterol level / MGI
insulin resistance / MGI
decreased heart rate / MGI
decreased glycogen level / MGI
abnormal platelet physiology / MGI
pancreatic islet hyperplasia / MGI
decreased circulating creatinine level / MGI
increased circulating glucose level / MGI
increased mean corpuscular hemoglobin / MGI
increased hemoglobin content / MGI
increased lung weight / MGI
pulmonary fibrosis / MGI
decreased physiological sensitivity to xenobiotic / MGI
decreased platelet aggregation / MGI
decreased birth body size / MGI
decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
preweaning lethality, complete penetrance / MGI
embryonic lethality, incomplete penetrance / MGI
embryonic lethality before implantation, incomplete penetrance / MGI
embryonic lethality during organogenesis, incomplete penetrance / MGI
lethality throughout fetal growth and development, incomplete penetrance / MGI
decreased fibroblast proliferation / MGI

Information from provider