C57BL/6NTac-Plin2tm1a(EUCOMM)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:05522
International strain nameC57BL/6NTac-Plin2tm1a(EUCOMM)Wtsi/WtsiOulu
Alternative nameEPD0045_1_D02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPlin2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolPlin2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0045_1_D02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased circulating total protein level / IMPC
IMPC phenotypes (gene matching)
  • increased circulating total protein level / IMPC
MGI phenotypes (gene matching)
  • decreased body weight / MGI
  • hyperactivity / MGI
  • decreased inflammatory response / MGI
  • male infertility / MGI
  • decreased susceptibility to hepatic steatosis / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating free fatty acid level / MGI
  • abnormal sebaceous gland physiology / MGI
  • delayed dark adaptation / MGI
  • abnormal milk composition / MGI
  • adipose tissue phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal eye electrophysiology / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • abnormal adipose tissue physiology / MGI
  • decreased circulating leptin level / MGI
  • abnormal maternal behavior / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • abnormal white fat cell morphology / MGI
  • decreased fat cell size / MGI
  • decreased epididymal fat pad weight / MGI
  • decreased liver triglyceride level / MGI
  • decreased total body fat amount / MGI
  • abnormal vitamin A metabolism / MGI
  • decreased food intake / MGI
  • small sebaceous gland / MGI
  • sebaceous gland hypoplasia / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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