B6Dnk;B6Brd;B6N-Tyrc-Brd Irf1tm1a(EUCOMM)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:05519
International strain nameB6Dnk;B6Brd;B6N-Tyrc-Brd Irf1tm1a(EUCOMM)Wtsi/WtsiOulu
Alternative nameEPD0027_2_B10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolIrf1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolIrf1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0027_2_B10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal immune system morphology / MGI
  • abnormal circulating alanine transaminase level / MGI
  • abnormal immune system physiology / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal immunoglobulin level / MGI
  • decreased susceptibility to induced arthritis / MGI
  • abnormal lymphocyte physiology / MGI
  • increased incidence of tumors by chemical induction / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • abnormal vascular wound healing / MGI
  • abnormal response to infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • increased double-positive T cell number / MGI
  • abnormal T cell proliferation / MGI
  • cellular phenotype / MGI
  • immune system phenotype / MGI
  • skeleton phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal T cell number / MGI
  • abnormal T cell morphology / MGI
  • decreased NK cell number / MGI
  • abnormal DNA repair / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased T-helper 2 cell number / MGI
  • decreased interferon-alpha secretion / MGI
  • decreased interferon-beta secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased circulating interferon-gamma level / MGI
  • decreased circulating interferon-gamma level / MGI
  • abnormal circulating interleukin-10 level / MGI
  • increased circulating interleukin-6 level / MGI
  • decreased circulating interleukin-2 level / MGI
  • abnormal circulating interleukin-4 level / MGI
  • increased circulating interleukin-4 level / MGI
  • increased circulating interleukin-13 level / MGI
  • increased circulating interleukin-3 level / MGI
  • increased circulating interleukin-5 level / MGI
  • abnormal cytokine level / MGI
  • abnormal thymus cell ratio / MGI
  • abnormal splenocyte morphology / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • increased lymphoma incidence / MGI

Literature references

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131
  • Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection.;Tomasello Elena, Naciri Karima, Chelbi Rabie, Bessou Gilles, Fries Anissa, Gressier Elise, Abbas Abdenour, Pollet Emeline, Pierre Philippe, Lawrence Toby, Vu Manh Thien-Phong, Dalod Marc, ;2018;The EMBO journal;37;5730; 30131424
  • Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection.;Schmalzl Angelika, Leupold Tamara, Kreiss Lucas, Waldner Maximilian, Schürmann Sebastian, Neurath Markus F, Becker Christoph, Wirtz Stefan, ;2022;Nature communications;13;496; 36175404
  • Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.;Place David E, Malireddi R K Subbarao, Kim Jieun, Vogel Peter, Yamamoto Masahiro, Kanneganti Thirumala-Devi, ;2021;Nature communications;12;; 33479228
  • Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer.;Karki Rajendra, Sharma Bhesh Raj, Lee Ein, Banoth Balaji, Malireddi R K Subbarao, Samir Parimal, Tuladhar Shraddha, Mummareddy Harisankeerth, Burton Amanda R, Vogel Peter, Kanneganti Thirumala-Devi, ;2020;JCI insight;5;; 32554929

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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