IMPC phenotypes (gene matching)
C57BL/6N-Strip2tm1.2Tac/Ieg
| Status | Available to order |
| EMMA ID | EM:05510 |
| International strain name | C57BL/6N-Strip2tm1.2Tac/Ieg |
| Alternative name | CAMP1 KO conv, Myoscape KO conv |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Strip2tm1.2Tac |
| Gene/Transgene symbol | Strip2 |
Information from provider
| Provider | Helmholtz Zentrum Muenchen |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen German Research Center for Environmental Health (GmbH) |
| Genetic information | Exons 3-8 have been flanked by loxP sites, as their genetic ablation should result in loss of function by deletion of the N1221 ORF-like protein domain and generation of a frameshift (see EMMA strain EM:05511). The constitutive knock-out mutation has been obtained by in vivo cre recombinase-mediated deletion. |
| Phenotypic information | TO BE PROVIDED |
| Breeding history | Targeting performed in C57BL/6N ES cells and confirmed by Southern blotting. Strip2 floxed mice were crossed to C57BL/6N cre-deleter mice to obtain the Strip2 null allele. Maintained on C57BL/6N background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTac, wild-type C57BL/6N |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.;Eden Matthias, Meder Benjamin, Völkers Mirko, Poomvanicha Montatip, Domes Katrin, Branchereau M, Marck P, Will Rainer, Bernt Alexander, Rangrez Ashraf, Busch Matthias, null null, Hrabě de Angelis Martin, Heymes Christophe, Rottbauer Wolfgang, Most Patrick, Hofmann Franz, Frey Norbert, ;2016;Nature communications;7;11317; 27122098