IMPC phenotypes (gene matching)
C57BL/6N-Traf7tm1.2Arte/Ieg
| Status | Available to order |
| EMMA ID | EM:05502 |
| International strain name | C57BL/6N-Traf7tm1.2Arte/Ieg |
| Alternative name | Traf7 KO conv |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Traf7tm1.2 |
| Gene/Transgene symbol | Traf7 |
Information from provider
| Provider | Helmholtz Zentrum Muenchen |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen German Research Center for Environmental Health (GmbH) |
| Genetic information | Exons 5-14 have been flanked by loxP sites, as their genetic ablation should result in loss of function by deletion of the RING finger motif and two out of seven WD repeats, and by generation of a frameshift (see EMMA strain EM:05503). The constitutive knock-out mutation has been obtained by in vivo cre recombinase-mediated deletion. |
| Phenotypic information | TO BE PROVIDED |
| Breeding history | Targeting performed in C57BL/6N ES cells and confirmed by Southern blotting. Traf7 floxed mice were crossed to C57BL/6N-Gt(ROSA)26Sortm16(cre)Arte mice to obtain the Traf7 null allele. Maintained on C57BL/6N background. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTac, wild-type C57BL/6N |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Meningioma / Orphanet_2495
- TRAF7-associated heart defect-digital anomalies-facial dysmorphism-motor and speech delay syndrome / Orphanet_592570