IMPC phenotypes (gene matching)
B6.129P2-Cx3cr1tm1Litt/WeiOrl
| Status | Available to order |
| EMMA ID | EM:00055 |
| International strain name | B6.129P2-Cx3cr1tm1Litt/WeiOrl |
| Alternative name | CX3CR1/GFP |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cx3cr1tm1Litt |
| Gene/Transgene symbol | Cx3cr1 |
Information from provider
| Provider | Steffen Jung |
| Provider affiliation | The Weizmann Institute of Science |
| Phenotypic information | Homozygous Cx3cr1/GFP mice have no overt phenotype. Cells expressing Cx3cr1 in heterozygous and homozygous mice are labelled by bright-green fluorescence, incl. microglia, monocytes, dendritic cells and NK cells. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- paresis / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- microgliosis / MGI
- homeostasis/metabolism phenotype / MGI
- paralysis / MGI
- demyelination / MGI
- brain inflammation / MGI
- abnormal leukocyte physiology / MGI
- increased neuron apoptosis / MGI
- abnormal microglial cell physiology / MGI
- abnormal vascular wound healing / MGI
- immune system phenotype / MGI
- abnormal vascular smooth muscle physiology / MGI
- brainstem hemorrhage / MGI
- decreased NK cell number / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
- abnormal dendritic cell physiology / MGI
- abnormal small intestinal villus morphology / MGI
- increased dendritic cell number / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- decreased monocyte cell number / MGI
- abnormal retina morphology / MGI
- nervous system phenotype / MGI
- impaired macrophage chemotaxis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- choroidal neovascularization / MGI
MGI phenotypes (gene matching)
- decreased monocyte cell number / MGI
- paralysis / MGI
- paresis / MGI
- demyelination / MGI
- abnormal retina morphology / MGI
- retinal degeneration / MGI
- brain inflammation / MGI
- no abnormal phenotype detected / MGI
- abnormal dendritic cell physiology / MGI
- abnormal leukocyte physiology / MGI
- no phenotypic analysis / MGI
- increased neuron apoptosis / MGI
- nervous system phenotype / MGI
- abnormal microglial cell physiology / MGI
- abnormal retinal photoreceptor layer morphology / MGI
- impaired macrophage chemotaxis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal vascular wound healing / MGI
- homeostasis/metabolism phenotype / MGI
- immune system phenotype / MGI
- choroidal neovascularization / MGI
- abnormal vascular smooth muscle physiology / MGI
- abnormal response to transplant / MGI
- brainstem hemorrhage / MGI
- retinal deposits / MGI
- decreased NK cell number / MGI
- abnormal small intestinal villus morphology / MGI
- increased dendritic cell number / MGI
- thin retinal outer nuclear layer / MGI
- microgliosis / MGI
- abnormal splenocyte physiology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
Literature references
- Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.;Jung S, Aliberti J, Graemmel P, Sunshine M J, Kreutzberg G W, Sher A, Littman D R, ;2000;Molecular and cellular biology;20;4106-14; 10805752
- Blood monocytes consist of two principal subsets with distinct migratory properties.;Geissmann Frederic, Jung Steffen, Littman Dan R, ;2003;Immunity;19;71-82; 12871640
- Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice.;Lantier Louis, Lacroix-Lamandé Sonia, Potiron Laurent, Metton Coralie, Drouet Françoise, Guesdon William, Gnahoui-David Audrey, Le Vern Yves, Deriaud Edith, Fenis Aurore, Rabot Sylvie, Descamps Amandine, Werts Catherine, Laurent Fabrice, ;2013;PLoS pathogens;9;e1003801; 24367259
- Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse.;Dénes Adám, Ferenczi Szilamér, Halász József, Környei Zsuzsanna, Kovács Krisztina J, ;2008;Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism;28;1707-21; 18575457
- In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue.;Khandoga Alexander Georg, Khandoga Andrej, Reichel Christoph Andreas, Bihari Peter, Rehberg Markus, Krombach Fritz, ;2009;PloS one;4;e4693; 19259262
- Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo.;Swinnen Nina, Smolders Sophie, Avila Ariel, Notelaers Kristof, Paesen Rik, Ameloot Marcel, Brône Bert, Legendre Pascal, Rigo Jean-Michel, ;2013;Glia;61;150-63; 23001583
- The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.;Woodfin Abigail, Voisin Mathieu-Benoit, Beyrau Martina, Colom Bartomeu, Caille Dorothée, Diapouli Frantzeska-Maria, Nash Gerard B, Chavakis Triantafyllos, Albelda Steven M, Rainger G Ed, Meda Paolo, Imhof Beat A, Nourshargh Sussan, ;2011;Nature immunology;12;761-9; 21706006
- p27kip1 Modulates the Morphology and Phagocytic Activity of Microglia.;Beeken Jolien, Kessels Sofie, Rigo Jean-Michel, Alpizar Yeranddy A, Nguyen Laurent, Brône Bert, ;2022;International journal of molecular sciences;23;11559-73; 36142366
- Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion.;Rigato Chiara, Swinnen Nina, Buckinx Roeland, Couillin Isabelle, Mangin Jean-Marie, Rigo Jean-Michel, Legendre Pascal, Le Corronc Hervé, ;2012;The Journal of neuroscience : the official journal of the Society for Neuroscience;32;301; 22915101
- Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo.;Smolders Silke, Smolders Sophie M T, Swinnen Nina, Gärtner Annette, Rigo Jean-Michel, Legendre Pascal, Brône Bert, ;2015;Frontiers in cellular neuroscience;9;102; 26300736
- Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury.;Van Broeckhoven Jana, Erens Céline, Sommer Daniela, Scheijen Elle, Sanchez Selien, Vidal Pia M, Dooley Dearbhaile, Van Breedam Elise, Quarta Alessandra, Ponsaerts Peter, Hendrix Sven, Lemmens Stefanie, ;2022;Journal of neuroinflammation;19;122426; 35488301
- Stretch-injury promotes microglia activation with enhanced phagocytic and synaptic stripping activities.;Procès Anthony, Alpizar Yeranddy A, Halliez Sophie, Brône Bert, Saudou Frédéric, Ris Laurence, Gabriele Sylvain, ;2024;Biomaterials;305;; 38134473