IMPC phenotypes (gene matching)
B6.129P2-Cx3cr1tm1Litt/WeiOrl
| Status | Available to order |
| EMMA ID | EM:00055 |
| Citation information | RRID:IMSR_EM:00055 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Cx3cr1tm1Litt/WeiOrl |
| Alternative name | CX3CR1/GFP |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cx3cr1tm1Litt |
| Gene/Transgene symbol | Cx3cr1 |
Information from provider
| Provider | Steffen Jung |
| Provider affiliation | The Weizmann Institute of Science |
| Phenotypic information | Homozygous Cx3cr1/GFP mice have no overt phenotype. Cells expressing Cx3cr1 in heterozygous and homozygous mice are labelled by bright-green fluorescence, incl. microglia, monocytes, dendritic cells and NK cells. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- paresis / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- microgliosis / MGI
- homeostasis/metabolism phenotype / MGI
- paralysis / MGI
- demyelination / MGI
- brain inflammation / MGI
- abnormal leukocyte physiology / MGI
- increased neuron apoptosis / MGI
- abnormal microglial cell physiology / MGI
- abnormal vascular wound healing / MGI
- immune system phenotype / MGI
- abnormal vascular smooth muscle physiology / MGI
- brainstem hemorrhage / MGI
- decreased NK cell number / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
- abnormal dendritic cell physiology / MGI
- abnormal small intestinal villus morphology / MGI
- increased dendritic cell number / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- decreased monocyte cell number / MGI
- abnormal retina morphology / MGI
- nervous system phenotype / MGI
- impaired macrophage chemotaxis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- choroidal neovascularization / MGI
MGI phenotypes (gene matching)
- decreased monocyte cell number / MGI
- paralysis / MGI
- paresis / MGI
- demyelination / MGI
- abnormal retina morphology / MGI
- retinal degeneration / MGI
- brain inflammation / MGI
- no abnormal phenotype detected / MGI
- abnormal dendritic cell physiology / MGI
- abnormal leukocyte physiology / MGI
- no phenotypic analysis / MGI
- increased neuron apoptosis / MGI
- nervous system phenotype / MGI
- abnormal microglial cell physiology / MGI
- abnormal retinal photoreceptor layer morphology / MGI
- impaired macrophage chemotaxis / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal vascular wound healing / MGI
- homeostasis/metabolism phenotype / MGI
- immune system phenotype / MGI
- choroidal neovascularization / MGI
- abnormal vascular smooth muscle physiology / MGI
- abnormal response to transplant / MGI
- brainstem hemorrhage / MGI
- retinal deposits / MGI
- decreased NK cell number / MGI
- abnormal small intestinal villus morphology / MGI
- increased dendritic cell number / MGI
- thin retinal outer nuclear layer / MGI
- microgliosis / MGI
- abnormal splenocyte physiology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
Literature references
- Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.;Jung S, Aliberti J, Graemmel P, Sunshine M J, Kreutzberg G W, Sher A, Littman D R, ;2000;Molecular and cellular biology;20;4106-14; 10805752
- Blood monocytes consist of two principal subsets with distinct migratory properties.;Geissmann Frederic, Jung Steffen, Littman Dan R, ;2003;Immunity;19;71-82; 12871640
- Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice.;Lantier Louis, Lacroix-Lamandé Sonia, Potiron Laurent, Metton Coralie, Drouet Françoise, Guesdon William, Gnahoui-David Audrey, Le Vern Yves, Deriaud Edith, Fenis Aurore, Rabot Sylvie, Descamps Amandine, Werts Catherine, Laurent Fabrice, ;2013;PLoS pathogens;9;e1003801; 24367259
- Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse.;Dénes Adám, Ferenczi Szilamér, Halász József, Környei Zsuzsanna, Kovács Krisztina J, ;2008;Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism;28;1707-21; 18575457
- In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue.;Khandoga Alexander Georg, Khandoga Andrej, Reichel Christoph Andreas, Bihari Peter, Rehberg Markus, Krombach Fritz, ;2009;PloS one;4;e4693; 19259262
- Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo.;Swinnen Nina, Smolders Sophie, Avila Ariel, Notelaers Kristof, Paesen Rik, Ameloot Marcel, Brône Bert, Legendre Pascal, Rigo Jean-Michel, ;2013;Glia;61;150-63; 23001583
- The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.;Woodfin Abigail, Voisin Mathieu-Benoit, Beyrau Martina, Colom Bartomeu, Caille Dorothée, Diapouli Frantzeska-Maria, Nash Gerard B, Chavakis Triantafyllos, Albelda Steven M, Rainger G Ed, Meda Paolo, Imhof Beat A, Nourshargh Sussan, ;2011;Nature immunology;12;761-9; 21706006
- p27kip1 Modulates the Morphology and Phagocytic Activity of Microglia.;Beeken Jolien, Kessels Sofie, Rigo Jean-Michel, Alpizar Yeranddy A, Nguyen Laurent, Brône Bert, ;2022;International journal of molecular sciences;23;11559-73; 36142366
- Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion.;Rigato Chiara, Swinnen Nina, Buckinx Roeland, Couillin Isabelle, Mangin Jean-Marie, Rigo Jean-Michel, Legendre Pascal, Le Corronc Hervé, ;2012;The Journal of neuroscience : the official journal of the Society for Neuroscience;32;301; 22915101
- Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo.;Smolders Silke, Smolders Sophie M T, Swinnen Nina, Gärtner Annette, Rigo Jean-Michel, Legendre Pascal, Brône Bert, ;2015;Frontiers in cellular neuroscience;9;102; 26300736
- Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury.;Van Broeckhoven Jana, Erens Céline, Sommer Daniela, Scheijen Elle, Sanchez Selien, Vidal Pia M, Dooley Dearbhaile, Van Breedam Elise, Quarta Alessandra, Ponsaerts Peter, Hendrix Sven, Lemmens Stefanie, ;2022;Journal of neuroinflammation;19;122426; 35488301
- Stretch-injury promotes microglia activation with enhanced phagocytic and synaptic stripping activities.;Procès Anthony, Alpizar Yeranddy A, Halliez Sophie, Brône Bert, Saudou Frédéric, Ris Laurence, Gabriele Sylvain, ;2024;Biomaterials;305;; 38134473