IMPC phenotypes (gene matching)
- decreased exploration in new environment / IMPC
C57BL/6N-Cited4tm1.2Arte/Ieg
| Status | Available to order |
| EMMA ID | EM:05489 |
| International strain name | C57BL/6N-Cited4tm1.2Arte/Ieg |
| Alternative name | Cited 4 KO conv |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cited4tm1.2Arte |
| Gene/Transgene symbol | Cited4 |
Information from provider
| Provider | Helmholtz Zentrum Muenchen |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen German Research Center for Environmental Health (GmbH) |
| Genetic information | The complete mouse Cited4 ORF is encoded by exon 1. Exon 1 including 1.5 kb of the promoter region has been flanked by loxP sites, as its genetic ablation should result in loss of function (see EMMA strain EM:05491). The constitutive knock-out mutation has been obtained by in vivo cre recombinase-mediated deletion. |
| Phenotypic information | TO BE PROVIDED |
| Breeding history | Targeting performed in C57BL/6N ES cells and confirmed by Southern blotting. Cited4 floxed mice were crossed to C57BL/6N-Gt(ROSA)26Sortm16(cre)Arte mice to obtain the Cited4 null allele. Maintained on C57BL/6N background. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTac, wild-type C57BL/6N |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- no phenotypic analysis / MGI
Literature references
- Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.;Bayindir-Buchhalter Irem, Wolff Gretchen, Lerch Sarah, Sijmonsma Tjeerd, Schuster Maximilian, Gronych Jan, Billeter Adrian T, Babaei Rohollah, Krunic Damir, Ketscher Lars, Spielmann Nadine, Hrabe de Angelis Martin, Ruas Jorge L, Müller-Stich Beat P, Heikenwalder Mathias, Lichter Peter, Herzig Stephan, Vegiopoulos Alexandros, ;2018;EMBO molecular medicine;10;; 29973382