B6.129P2-Tacr1tm1Sph/H

Status

Available to order

EMMA IDEM:05452
International strain nameB6.129P2-Tacr1tm1Sph/H
Alternative nameNK1 Receptor knock-out / Backcrossed on C57BL/6
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTacr1tm1Sph
Gene/Transgene symbolTacr1

Information from provider

ProviderS P Hunt
Provider affiliationWindeyer Institute of Medical Sciences, University College London
Genetic informationTargeting construct for NK1 (or Tacr1) receptor is derived from 129/Sv DNA. A reporter/selection cassette (IRES-Gal-MC1-Neo) was inserted into exon 1 of the targeted allele, rendering the mRNA out-of-frame and thus no functional NK1 receptor can be produced.
Phenotypic informationDeletion of Tacr1/NK1 receptor gene. Viable, normal breeding pattern. No obvious phenotype.
Breeding historyBackcrossed for more than 10 generations.
References
  • Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.;De Felipe C, Herrero J F, O'Brien J A, Palmer J A, Doyle C A, Smith A J, Laird J M, Belmonte C, Cervero F, Hunt S P, ;1998;Nature;392;394-7; 9537323
  • Genetic background influences the behavioural and molecular consequences of neurokinin-1 receptor knockout.;McCutcheon J E, Fisher A S, Guzdar E, Wood S A, Lightman S L, Hunt S P, ;2008;The European journal of neuroscience;27;683-90; 18279320
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6
Breeding at archiving centreMales were archived upon arrival at the archiving centre. No breeding was carried out.

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • hyperactivity / MGI
  • impaired coordination / MGI
  • abnormal dopamine level / MGI
  • abnormal pain threshold / MGI
  • abnormal noradrenaline level / MGI
  • impaired conditioned place preference behavior / MGI
  • impaired behavioral response to addictive substance / MGI
  • impaired behavioral response to morphine / MGI
  • abnormal nervous system physiology / MGI
  • abnormal thermosensation / MGI
  • decreased inflammatory response / MGI
  • increased airway responsiveness / MGI
  • abnormal touch/ nociception / MGI
  • abnormal respiratory mucosa goblet cell morphology / MGI
  • abnormal chemical nociception / MGI
  • joint inflammation / MGI
  • decreased nerve fiber response intensity / MGI
  • hyperalgesia / MGI
  • abnormal pulmonary respiratory rate / MGI
  • decreased aggression / MGI
MGI phenotypes (gene matching)
  • decreased anxiety-related response / MGI
  • hyperactivity / MGI
  • impaired coordination / MGI
  • abnormal body temperature homeostasis / MGI
  • abnormal humoral immune response / MGI
  • decreased inflammatory response / MGI
  • abnormal dopamine level / MGI
  • increased airway responsiveness / MGI
  • abnormal touch/ nociception / MGI
  • abnormal pain threshold / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal respiratory mucosa goblet cell morphology / MGI
  • abnormal mast cell physiology / MGI
  • decreased circulating corticosterone level / MGI
  • abnormal chemical nociception / MGI
  • abnormal nociception after inflammation / MGI
  • joint inflammation / MGI
  • decreased vascular permeability / MGI
  • decreased nerve fiber response intensity / MGI
  • abnormal nervous system physiology / MGI
  • abnormal thermosensation / MGI
  • abnormal noradrenaline level / MGI
  • abnormal neuron physiology / MGI
  • hyperalgesia / MGI
  • hyporesponsive to tactile stimuli / MGI
  • decreased aggression / MGI
  • increased chemical nociceptive threshold / MGI
  • abnormal physiological response to xenobiotic / MGI
  • impaired conditioned place preference behavior / MGI
  • impaired behavioral response to xenobiotic / MGI
  • impaired behavioral response to addictive substance / MGI
  • impaired behavioral response to morphine / MGI
  • decreased vocalization / MGI
  • abnormal pulmonary respiratory rate response / MGI

Literature references

  • Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.;De Felipe C, Herrero J F, O'Brien J A, Palmer J A, Doyle C A, Smith A J, Laird J M, Belmonte C, Cervero F, Hunt S P, ;1998;Nature;392;394-7; 9537323
  • Genetic background influences the behavioural and molecular consequences of neurokinin-1 receptor knockout.;McCutcheon J E, Fisher A S, Guzdar E, Wood S A, Lightman S L, Hunt S P, ;2008;The European journal of neuroscience;27;683-90; 18279320

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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