IMPC phenotypes (gene matching)
B6(Cg)-Grik4tm1.1(cre)Slab/H
| Status | Available to order |
| EMMA ID | EM:05449 |
| International strain name | B6(Cg)-Grik4tm1.1(cre)Slab/H |
| Alternative name | KA1-Cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Grik4tm1.1(cre)Slab |
| Gene/Transgene symbol | Grik4 |
Information from provider
| Provider | Ralf Schoepfer |
| Provider affiliation | CBU, UCL |
| Genetic information | http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=602859 |
| Phenotypic information | Cre recombinase-expressing mouse with restricted expression in subregions of the hippocampus, mainly in CA3 and absent in CA1. No obvious phenotype in the absence of a target allele. |
| Breeding history | Originally produced from ES cells derived from C57BL/6NTacfBR, then backcrossed to C57BL/6J, then mated with a Flp deleter strain that was mainly C57BL/6J. Since then further backcrossed to C57BL/6J. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J |
| Breeding at archiving centre | Males were archived upon arrival at the archiving centre. No breeding was carried out. |
Disease and phenotype information
Literature references
- Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.;Filosa Alessandro, Paixão Sónia, Honsek Silke D, Carmona Maria A, Becker Lore, Feddersen Berend, Gaitanos Louise, Rudhard York, Schoepfer Ralf, Klopstock Thomas, Kullander Klas, Rose Christine R, Pasquale Elena B, Klein Rüdiger, ;2009;Nature neuroscience;12;1285-92; 19734893