| Status | Available to order |
| EMMA ID | EM:05446 |
| Citation information | RRID:IMSR_EM:05446 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Gjc2tm2.1Kwi/Cnrm |
| Alternative name | Cx47M282T |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gjc2tm2.1Kwi |
| Gene/Transgene symbol | Gjc2 |
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | In this mouse line the Cx47 (Gjc2) coding DNA is replaced by the Cx47M282T point mutation followed by an IRES-LacZ reporter DNA. The point mutation and the reporter gene are controlled by the endogenous Cx47 promoter. |
| Phenotypic information | Homozygous Cx47M282T mutants show myelin deficits during early developmental stages (hypermyelination) accompanied by myelin vacuolation. |
| Breeding history | Founder animals were backcrossed to C57BL/6 nine times (more than 99%). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
