| Status | Available to order |
| EMMA ID | EM:05446 |
| International strain name | B6.Cg-Gjc2tm2.1Kwi/Cnrm |
| Alternative name | Cx47M282T |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gjc2tm2.1Kwi |
| Gene/Transgene symbol | Gjc2 |
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | In this mouse line the Cx47 (Gjc2) coding DNA is replaced by the Cx47M282T point mutation followed by an IRES-LacZ reporter DNA. The point mutation and the reporter gene are controlled by the endogenous Cx47 promoter. |
| Phenotypic information | Homozygous Cx47M282T mutants show myelin deficits during early developmental stages (hypermyelination) accompanied by myelin vacuolation. |
| Breeding history | Founder animals were backcrossed to C57BL/6 nine times (more than 99%). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
