C3H/HeOuJ-MaoaTg(H2-K1-Ifnb1)8Seif/Orl

Status

Available to order

EMMA IDEM:05408
Citation informationRRID:IMSR_EM:05408 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC3H/HeOuJ-MaoaTg(H2-K1-Ifnb1)8Seif/Orl
Alternative nameMaoaTg(H2-K1-Ifnb1)8Seif or Tg 8 or MAOA KO
Strain typeTransgenic Strains
Allele/Transgene symbolMaoaTg(H2-K1-Ifnb1)8Seif
Gene/Transgene symbolMaoa

Information from provider

ProviderIsabelle Seif
Provider affiliationNeuropharmacologie, Faculte de pharmacie (Universite Paris-Sud)
Genetic informationThese H2-IFNB transgenic mice have the coding region of the murine interferon beta 1 (Ifnb1) gene placed behind the proximal region of the promoter of the murine histocompatibility 2, K1, K region (H2-K1) gene. The transgene integrated into the X-linked monoamine oxidase A (Maoa) gene, replacing Maoa exons 2-3 and abolishing Maoa gene function.
Phenotypic informationThese mice may be useful for studying MAOA-related aggression and abnormal development of neural circuits under excess serotonin.
Breeding historybrother/sister mating
References
  • Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.;Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, Shih J C, ;1995;Science (New York, N.Y.);268;1763-6; 7792602
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C3H/HeOuJ males, wild-type C3H/HeOuJ females
Breeding at archiving centreTransgenic on X-chromosome. Hemizygous males have been crossed with wild-type females to obtain embryos.
Stage of embryos2-cell

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • decreased left ventricle systolic pressure / MGI
  • abnormal myocardial fiber physiology / MGI
  • decreased response of heart to induced stress / MGI

Literature references

  • Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.;Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, Shih J C, ;1995;Science (New York, N.Y.);268;1763-6; 7792602

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).