FVB.129P2-Csf3r^tm2Eur/Cnrm

Status	Available to order
EMMA ID	EM:00054
Citation information	RRID:IMSR_EM:00054 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	FVB.129P2-Csf3r^tm2Eur/Cnrm
Alternative name	Csfgr-KO
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Csf3r^tm2Eur
Gene/Transgene symbol	Csf3r

Information from provider

Provider	Mirjam Hermans
Provider affiliation	Erasmus Univ.-Inst. Hematology
Genetic information	Inactivation of the Csf3r (Csfgr, G-CSFR) gene. Exons 7 to 17 are replaced by a PGK-neo gene (the total number of exons in the Csf3r gene is 17).
Phenotypic information	Reduced numbers of bone marrow and blood neutrophils.
References	None available

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Chronic neutrophilic leukemia / Orphanet_86829
Atypical chronic myeloid leukemia / Orphanet_98824
Autosomal recessive severe congenital neutropenia due to CSF3R deficiency / Orphanet_420702
Hereditary neutrophilia / Orphanet_279943

IMPC phenotypes (gene matching)

small superior vagus ganglion / IMPC
preweaning lethality, incomplete penetrance / IMPC
small testis / IMPC
abnormal testis morphology / IMPC
hydrometra / IMPC
enlarged heart / IMPC
abnormal heart morphology / IMPC

MGI phenotypes (allele matching)

decreased neutrophil cell number / MGI

MGI phenotypes (gene matching)

decreased neutrophil cell number / MGI
decreased monocyte cell number / MGI
increased bone marrow cell number / MGI
decreased bone marrow cell number / MGI
decreased granulocyte number / MGI
abnormal hematopoietic system morphology/development / MGI
abnormal bone marrow cell morphology/development / MGI
abnormal myeloblast morphology/development / MGI
abnormal neutrophil differentiation / MGI
abnormal neutrophil physiology / MGI
abnormal monocyte morphology / MGI
decreased hematopoietic stem cell number / MGI
immune system phenotype / MGI
abnormal common myeloid progenitor cell morphology / MGI
impaired neutrophil chemotaxis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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FVB.129P2-Csf3rtm2Eur/Cnrm