B6129S8-Tc(HSA21)1TybEmcf/H
| Status | Available to order |
| EMMA ID | EM:05291 |
| International strain name | B6129S8-Tc(HSA21)1TybEmcf/H |
| Alternative name | Tc1Tyb |
| Strain type | Other |
| Allele/Transgene symbol | Tc(HSA21)1TybEmcf |
| Gene/Transgene symbol | Tc(HSA21)1TybEmcf |
Information from provider
| Provider | Victor Tybulewicz |
| Provider affiliation | Medical Research Council |
| Additional owner | The strain was jointly produced with Prof. Elizabeth Fisher, MRC Prion Unit |
| Genetic information | Chromosome mediated gene transfer was used to insert human chromosome 21 from a human cell line into mouse ES cells and hence into mice. |
| Phenotypic information | Affected mice suffer from learning abnormalities, reduced long-term potentiation in the hippocampus, heart and brain developmental defects, craniofacial dysmorphology (this strain models human Down syndrome). |
| Breeding history | The extra human chromosome 21 is only transmitted through the female germline, so the strain is maintained by crossing Tc1 females to male B6129S8F1 mice. Transmitting females only transmit the human chromosome to up to 40% of their offspring on this genetic background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | wild-type 0, heterozygous 0 |
| Breeding at archiving centre | TC1 females and B6129S8 F1 breeding pairs were imported. Breeding colonies of both strains were established at Harwell prior to archiving. |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.;O'Doherty Aideen, Ruf Sandra, Mulligan Claire, Hildreth Victoria, Errington Mick L, Cooke Sam, Sesay Abdul, Modino Sonie, Vanes Lesley, Hernandez Diana, Linehan Jacqueline M, Sharpe Paul T, Brandner Sebastian, Bliss Timothy V P, Henderson Deborah J, Nizetic Dean, Tybulewicz Victor L J, Fisher Elizabeth M C, ;2005;Science (New York, N.Y.);309;2033-7; 16179473
- Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310