IMPC phenotypes (gene matching)
B6;129-Hint1tm1Ibw/Ieg
| Status | Available to order |
| EMMA ID | EM:05279 |
| International strain name | B6;129-Hint1tm1Ibw/Ieg |
| Alternative name | HINT1 Knockout mice |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Hint1tm1Ibw |
| Gene/Transgene symbol | Hint1 |
Information from provider
| Provider | Christoph Turck |
| Provider affiliation | Molecular Neurogenetics, Max Planck Institute of Psychiatry |
| Additional owner | Dr. Haiyang Li, Herbert Comprehensive Cancer Center, Columbia University Medical Center, NY, United States |
| Genetic information | This mouse line was originally created by Dr. I. Bernard Weinstein. Those mice were infected with some pathogens. Due to this reason, a new embryo transfer into foster mothers was done. |
| Phenotypic information | Hint1 knock-out mice exhibited more anxiety-related behaviour than wild-type mice in elevated plus-maze and dark light-box test. |
| Breeding history | For 6 generations the heterozygous male and female mice were mated to generate the homozygous mice. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N, wild-type C57BL/6N |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive axonal neuropathy with neuromyotonia / Orphanet_324442
Literature references
- The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage.;Li Haiyang, Balajee Adayabalam S, Su Tao, Cen Bo, Hei Tom K, Weinstein I Bernard, ;2008;The Journal of cell biology;183;253-65; 18852295
- Hint1 is a haplo-insufficient tumor suppressor in mice.;Li H, Zhang Y, Su T, Santella R M, Weinstein I B, ;2006;Oncogene;25;713-21; 16186798
- Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis.;Su Tao, Suzui Masumi, Wang Lei, Lin Chyuan-Sheng, Xing Wang-Qiu, Weinstein I Bernard, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;7824-9; 12810953
- Increased anxiety-related behaviour in Hint1 knockout mice.;Varadarajulu Jeeva, Lebar Maria, Krishnamoorthy Gurumoorthy, Habelt Sonja, Lu Jia, Bernard Weinstein I, Li Haiyang, Holsboer Florian, Turck Christoph W, Touma Chadi, ;2011;Behavioural brain research;220;305-11; 21316396