MGI phenotypes (allele matching)
C57BL/6J-Fgf9Aca12/Ieg
| Status | Available to order |
| EMMA ID | EM:05137 |
| International strain name | C57BL/6J-Fgf9Aca12/Ieg |
| Alternative name | Aca12 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Fgf9Aca12, |
| Gene/Transgene symbol | Fgf9 |
Information from provider
| Provider | Oliver Puk |
| Provider affiliation | Institut fuer Entwicklungsgenetik, AG Graw, Helmholtz Zentrum Muenchen |
| Genetic information | ENU induced Fgf9 Y162C mutation. Disclaimer - Special restrictions: 1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols. 2) Some lines showed low penetrance of the phenotype. 3) Only sperm available. Rederivation service can not be offered. 4) EMMA quality control standards may not apply for these strains. 5) EMMA has not verified the breeding performance and the genetic background of the strains. The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt. |
| Phenotypic information | Aca12 is characterized by microphthalmia and microphakia. |
| Breeding history | Incross, 10 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Multiple synostoses syndrome / Orphanet_3237
Literature references
- The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth.;Puk Oliver, Möller Gabriele, Geerlof Arie, Krowiorz Kathrin, Ahmad Nafees, Wagner Sibylle, Adamski Jerzy, de Angelis Martin Hrabé, Graw Jochen, ;2011;PloS one;6;e23678; 21858205
- Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice.;Garrett Lillian, Becker Lore, Rozman Jan, Puk Oliver, Stoeger Tobias, Yildirim Ali Önder, Bohla Alexander, Eickelberg Oliver, Hans Wolfgang, Prehn Cornelia, Adamski Jerzy, Klopstock Thomas, Rácz Ildikó, Zimmer Andreas, Klingenspor Martin, Fuchs Helmut, Gailus-Durner Valerie, Wurst Wolfgang, Hrabě de Angelis Martin, Graw Jochen, Hölter Sabine M, ;2018;Molecular neurobiology;55;4580-4595; 28695538