C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:05128
International strain nameC57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0370_6_H05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAcp2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolAcp2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0370_6_H05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac
Breeding at archiving centreChimeras were mated to C57BL/6N Tac USA and maintained on this background thereafter.

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased bone mineral density / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • abnormal bone mineralization / IMPC
  • abnormal bone structure / IMPC
  • abnormal behavior / IMPC
  • increased B cell number / IMPC
  • decreased T cell number / IMPC
  • decreased CD4-positive, alpha-beta T cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • increased bone mineral content / IMPC
IMPC phenotypes (gene matching)
  • increased B cell number / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased hemoglobin content / IMPC
  • decreased CD4-positive, alpha-beta T cell number / IMPC
  • decreased T cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • abnormal bone structure / IMPC
  • abnormal bone mineralization / IMPC
  • decreased bone mineral density / IMPC
  • increased bone mineral content / IMPC
  • abnormal behavior / IMPC
MGI phenotypes (gene matching)
  • kyphoscoliosis / MGI
  • abnormal microglial cell morphology / MGI
  • abnormal vertebral body morphology / MGI
  • kyphosis / MGI
  • lordosis / MGI
  • abnormal hair follicle morphology / MGI
  • alopecia / MGI
  • delayed hair appearance / MGI
  • tremors / MGI
  • abnormal cerebellum morphology / MGI
  • small cerebellum / MGI
  • thin external granule cell layer / MGI
  • abnormal cerebellar Purkinje cell layer / MGI
  • ectopic Purkinje cell / MGI
  • absent cerebellar granule layer / MGI
  • abnormal cerebellar molecular layer / MGI
  • abnormal CNS glial cell morphology / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • abnormal dermal layer morphology / MGI
  • decreased body height / MGI
  • decreased body weight / MGI
  • ataxia / MGI
  • postnatal growth retardation / MGI
  • astrocytosis / MGI
  • abnormal compact bone morphology / MGI
  • tonic-clonic seizures / MGI
  • abnormal vertebral pedicle morphology / MGI
  • abnormal vertebral column morphology / MGI
  • abnormal lysosome morphology / MGI
  • accumulation of giant lysosomes in kidney/renal tubule cells / MGI
  • behavior/neurological phenotype / MGI
  • abnormal Purkinje cell dendrite morphology / MGI
  • thin hair shaft / MGI
  • increased trabecular bone connectivity density / MGI
  • decreased bone mineralization / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).