B6.Cg-Tg(Col6a1-cre)1Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:05102 |
| Citation information | RRID:IMSR_EM:05102 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Col6a1-cre)1Gkl/Flmg |
| Alternative name | CollagenVI-Cre [CBA.B6-Tg(Col6a1-cre)444Gkl/Flmg] |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Col6a1-cre)1Gkl |
| Gene/Transgene symbol | Tg(Col6a1-cre)1Gkl |
Information from provider
| Provider | George Kollias |
| Provider affiliation | B.S.R.C. |
| Genetic information | The transgene contains a 7.5 kb of collagen VI enhancer/promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kb fragment from the human growth hormone gene. |
| Phenotypic information | Tool used together with conditional systems for specific expression of the targeted gene in synovial fibroblasts, articular chondrocytes, skeletal myocytes, intestinal myofibroblasts, dermal fibroblasts, and keratinocytes. |
| Breeding history | The strain is backcrossed in C57BL/6J for at least 10 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6 males, wild-type females |
| Stage of embryos | 2-cell |
Literature references
- Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases.;Armaka Maria, Apostolaki Maria, Jacques Peggy, Kontoyiannis Dimitris L, Elewaut Dirk, Kollias George, ;2008;The Journal of experimental medicine;205;331-7; 18250193