B6Brd;B6N-Tyrc-Brd Slx4tm1a(EUCOMM)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:05091
International strain nameB6Brd;B6N-Tyrc-Brd Slx4tm1a(EUCOMM)Wtsi/WtsiCnbc
Alternative nameEPD0028_7_A08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSlx4tm1a(EUCOMM)Wtsi
Gene/Transgene symbolSlx4
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0028_7_A08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • preweaning lethality, incomplete penetrance / IMPC
IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (allele matching)
  • decreased leukocyte cell number / MGI
  • abnormal cranium morphology / MGI
  • enlarged cranium / MGI
  • domed cranium / MGI
  • abnormal cerebral cortex morphology / MGI
  • dilated lateral ventricles / MGI
  • abnormal third ventricle morphology / MGI
  • obstructive hydrocephaly / MGI
  • absent mature ovarian follicles / MGI
  • absent corpus luteum / MGI
  • abnormal spermatogenesis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • abnormal cornea morphology / MGI
  • corneal opacity / MGI
  • abnormal pupil morphology / MGI
  • abnormal iris morphology / MGI
  • absent optic nerve / MGI
  • postnatal growth retardation / MGI
  • hydroencephaly / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • decreased litter size / MGI
  • abnormal eye morphology / MGI
  • abnormal tooth morphology / MGI
  • abnormal lymphopoiesis / MGI
  • oligozoospermia / MGI
  • abnormal retinal vasculature morphology / MGI
  • increased erythrocyte cell number / MGI
  • thrombocytopenia / MGI
  • nervous system phenotype / MGI
  • abnormal eyelid aperture / MGI
  • abnormal spine curvature / MGI
  • vertebral fusion / MGI
  • absent oocytes / MGI
  • azoospermia / MGI
  • impaired glucose tolerance / MGI
  • increased circulating glucose level / MGI
  • thin cerebral cortex / MGI
  • early cellular replicative senescence / MGI
  • abnormal male germ cell apoptosis / MGI
  • abnormal primordial germ cell morphology / MGI
  • decreased common myeloid progenitor cell number / MGI
  • chromosomal instability / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced cell death / MGI
  • increased caudal vertebrae number / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • abnormal eye size / MGI
MGI phenotypes (gene matching)
  • decreased leukocyte cell number / MGI
  • abnormal cranium morphology / MGI
  • enlarged cranium / MGI
  • domed cranium / MGI
  • abnormal cerebral cortex morphology / MGI
  • dilated lateral ventricles / MGI
  • abnormal third ventricle morphology / MGI
  • obstructive hydrocephaly / MGI
  • absent mature ovarian follicles / MGI
  • absent corpus luteum / MGI
  • small testis / MGI
  • abnormal spermatogenesis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • abnormal cornea morphology / MGI
  • corneal opacity / MGI
  • abnormal pupil morphology / MGI
  • abnormal iris morphology / MGI
  • absent optic nerve / MGI
  • postnatal growth retardation / MGI
  • hydroencephaly / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • decreased litter size / MGI
  • abnormal eye morphology / MGI
  • abnormal tooth morphology / MGI
  • abnormal lymphopoiesis / MGI
  • oligozoospermia / MGI
  • abnormal eye size / MGI
  • abnormal retinal vasculature morphology / MGI
  • no phenotypic analysis / MGI
  • increased erythrocyte cell number / MGI
  • thrombocytopenia / MGI
  • nervous system phenotype / MGI
  • abnormal eyelid aperture / MGI
  • induced chromosome breakage / MGI
  • abnormal spine curvature / MGI
  • vertebral fusion / MGI
  • absent oocytes / MGI
  • azoospermia / MGI
  • impaired glucose tolerance / MGI
  • increased circulating glucose level / MGI
  • thin cerebral cortex / MGI
  • early cellular replicative senescence / MGI
  • abnormal DNA repair / MGI
  • abnormal male germ cell apoptosis / MGI
  • abnormal primordial germ cell morphology / MGI
  • decreased common myeloid progenitor cell number / MGI
  • chromosomal instability / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced cell death / MGI
  • increased caudal vertebrae number / MGI
  • abnormal telomere morphology / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI
  • embryonic lethality, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI

Literature references

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131

Information on how we integrate external resources can be found here

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Availabilities

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Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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