B6Brd;B6N-Tyrc-Brd Slc38a10tm1a(EUCOMM)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:05087
International strain nameB6Brd;B6N-Tyrc-Brd Slc38a10tm1a(EUCOMM)Wtsi/WtsiCnbc
Alternative nameEPD0058_1_A04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSlc38a10tm1a(EUCOMM)Wtsi
Gene/Transgene symbolSlc38a10
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0058_1_A04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131
  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.;de Angelis Martin Hrabě, Nicholson George, Selloum Mohammed, White Jacqui, Morgan Hugh, Ramirez-Solis Ramiro, Sorg Tania, Wells Sara, Fuchs Helmut, Fray Martin, Adams David J, Adams Niels C, Adler Thure, Aguilar-Pimentel Antonio, Ali-Hadji Dalila, Amann Gregory, André Philippe, Atkins Sarah, Auburtin Aurelie, Ayadi Abdel, Becker Julien, Becker Lore, Bedu Elodie, Bekeredjian Raffi, Birling Marie-Christine, Blake Andrew, Bottomley Joanna, Bowl Mike, Brault Véronique, Busch Dirk H, Bussell James N, Calzada-Wack Julia, Cater Heather, Champy Marie-France, Charles Philippe, Chevalier Claire, Chiani Francesco, Codner Gemma F, Combe Roy, Cox Roger, Dalloneau Emilie, Dierich André, Di Fenza Armida, Doe Brendan, Duchon Arnaud, Eickelberg Oliver, Esapa Chris T, El Fertak Lahcen, Feigel Tanja, Emelyanova Irina, Estabel Jeanne, Favor Jack, Flenniken Ann, Gambadoro Alessia, Garrett Lilian, Gates Hilary, Gerdin Anna-Karin, Gkoutos George, Greenaway Simon, Glasl Lisa, Goetz Patrice, Da Cruz Isabelle Goncalves, Götz Alexander, Graw Jochen, Guimond Alain, Hans Wolfgang, Hicks Geoff, Hölter Sabine M, Höfler Heinz, Hancock John M, Hoehndorf Robert, Hough Tertius, Houghton Richard, Hurt Anja, Ivandic Boris, Jacobs Hughes, Jacquot Sylvie, Jones Nora, Karp Natasha A, Katus Hugo A, Kitchen Sharon, Klein-Rodewald Tanja, Klingenspor Martin, Klopstock Thomas, Lalanne Valerie, Leblanc Sophie, Lengger Christoph, le Marchand Elise, Ludwig Tonia, Lux Aline, McKerlie Colin, Maier Holger, Mandel Jean-Louis, Marschall Susan, Mark Manuel, Melvin David G, Meziane Hamid, Micklich Kateryna, Mittelhauser Christophe, Monassier Laurent, Moulaert David, Muller Stéphanie, Naton Beatrix, Neff Frauke, Nolan Patrick M, Nutter Lauryl Mj, Ollert Markus, Pavlovic Guillaume, Pellegata Natalia S, Peter Emilie, Petit-Demoulière Benoit, Pickard Amanda, Podrini Christine, Potter Paul, Pouilly Laurent, Puk Oliver, Richardson David, Rousseau Stephane, Quintanilla-Fend Leticia, Quwailid Mohamed M, Racz Ildiko, Rathkolb Birgit, Riet Fabrice, Rossant Janet, Roux Michel, Rozman Jan, Ryder Ed, Salisbury Jennifer, Santos Luis, Schäble Karl-Heinz, Schiller Evelyn, Schrewe Anja, Schulz Holger, Steinkamp Ralf, Simon Michelle, Stewart Michelle, Stöger Claudia, Stöger Tobias, Sun Minxuan, Sunter David, Teboul Lydia, Tilly Isabelle, Tocchini-Valentini Glauco P, Tost Monica, Treise Irina, Vasseur Laurent, Velot Emilie, Vogt-Weisenhorn Daniela, Wagner Christelle, Walling Alison, Weber Bruno, Wendling Olivia, Westerberg Henrik, Willershäuser Monja, Wolf Eckhard, Wolter Anne, Wood Joe, Wurst Wolfgang, Yildirim Ali Önder, Zeh Ramona, Zimmer Andreas, Zimprich Annemarie, null null, Holmes Chris, Steel Karen P, Herault Yann, Gailus-Durner Valérie, Mallon Ann-Marie, Brown Steve Dm, ;2015;Nature genetics;47;969-978; 26214591

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased bone mineral density / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal maxilla morphology / IMPC
  • decreased body length / IMPC
  • decreased body weight / IMPC
  • increased mean corpuscular volume / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • abnormal bone structure / IMPC
  • decreased lean body mass / IMPC
  • decreased circulating serum albumin level / IMPC
  • increased circulating iron level / IMPC
  • decreased total body fat amount / IMPC
  • decreased bone mineral content / IMPC
  • lipid deposition / IMPC
  • lipid depletion / IMPC
IMPC phenotypes (gene matching)
  • lipid deposition / IMPC
  • decreased body length / IMPC
  • decreased body weight / IMPC
  • abnormal cranium morphology / IMPC
  • lipid depletion / IMPC
  • increased mean corpuscular volume / IMPC
  • short tibia / IMPC
  • decreased circulating serum albumin level / IMPC
  • increased bone mineral content / IMPC
  • abnormal bone structure / IMPC
  • abnormal gait / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • thrombocytopenia / IMPC
  • decreased circulating triglyceride level / IMPC
  • abnormal response to tactile stimuli / IMPC
  • decreased total body fat amount / IMPC
  • abnormal startle reflex / IMPC
  • decreased lean body mass / IMPC
  • decreased circulating calcium level / IMPC
  • decreased circulating sodium level / IMPC
  • decreased hemoglobin content / IMPC
  • abnormal eye morphology / IMPC
  • decreased circulating amylase level / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased bone mineral content / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased circulating phosphate level / IMPC
  • abnormal retina morphology / IMPC
  • decreased circulating total protein level / IMPC
  • decreased grip strength / IMPC
  • abnormal maxilla morphology / IMPC
  • decreased bone mineral density / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
  • increased circulating iron level / IMPC
MGI phenotypes (allele matching)
  • fragile skeleton / MGI
  • decreased bone mineral density / MGI
  • abnormal liver physiology / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • decreased lean body mass / MGI
  • decreased length of long bones / MGI
  • increased energy expenditure / MGI
  • increased oxygen consumption / MGI
  • decreased circulating serum albumin level / MGI
  • increased circulating creatinine level / MGI
  • decreased circulating amylase level / MGI
  • decreased total body fat amount / MGI
  • decreased bone mineral content / MGI
  • decreased circulating calcium level / MGI
  • abnormal cranium morphology / MGI
  • abnormal maxilla morphology / MGI
  • decreased hemoglobin content / MGI
  • decreased erythrocyte cell number / MGI
  • decreased circulating alkaline phosphatase level / MGI
  • decreased circulating total protein level / MGI
MGI phenotypes (gene matching)
  • fragile skeleton / MGI
  • decreased bone mineral density / MGI
  • decreased circulating calcium level / MGI
  • abnormal cranium morphology / MGI
  • abnormal maxilla morphology / MGI
  • abnormal liver physiology / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • decreased hemoglobin content / MGI
  • decreased erythrocyte cell number / MGI
  • decreased circulating alkaline phosphatase level / MGI
  • decreased lean body mass / MGI
  • decreased length of long bones / MGI
  • increased energy expenditure / MGI
  • increased oxygen consumption / MGI
  • decreased circulating serum albumin level / MGI
  • increased circulating creatinine level / MGI
  • decreased circulating total protein level / MGI
  • decreased circulating amylase level / MGI
  • decreased total body fat amount / MGI
  • decreased bone mineral content / MGI

Literature references

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.;White Jacqueline K, Gerdin Anna-Karin, Karp Natasha A, Ryder Ed, Buljan Marija, Bussell James N, Salisbury Jennifer, Clare Simon, Ingham Neil J, Podrini Christine, Houghton Richard, Estabel Jeanne, Bottomley Joanna R, Melvin David G, Sunter David, Adams Niels C, null null, Tannahill David, Logan Darren W, Macarthur Daniel G, Flint Jonathan, Mahajan Vinit B, Tsang Stephen H, Smyth Ian, Watt Fiona M, Skarnes William C, Dougan Gordon, Adams David J, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, ;2013;Cell;154;452-64; 23870131
  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.;de Angelis Martin Hrabě, Nicholson George, Selloum Mohammed, White Jacqui, Morgan Hugh, Ramirez-Solis Ramiro, Sorg Tania, Wells Sara, Fuchs Helmut, Fray Martin, Adams David J, Adams Niels C, Adler Thure, Aguilar-Pimentel Antonio, Ali-Hadji Dalila, Amann Gregory, André Philippe, Atkins Sarah, Auburtin Aurelie, Ayadi Abdel, Becker Julien, Becker Lore, Bedu Elodie, Bekeredjian Raffi, Birling Marie-Christine, Blake Andrew, Bottomley Joanna, Bowl Mike, Brault Véronique, Busch Dirk H, Bussell James N, Calzada-Wack Julia, Cater Heather, Champy Marie-France, Charles Philippe, Chevalier Claire, Chiani Francesco, Codner Gemma F, Combe Roy, Cox Roger, Dalloneau Emilie, Dierich André, Di Fenza Armida, Doe Brendan, Duchon Arnaud, Eickelberg Oliver, Esapa Chris T, El Fertak Lahcen, Feigel Tanja, Emelyanova Irina, Estabel Jeanne, Favor Jack, Flenniken Ann, Gambadoro Alessia, Garrett Lilian, Gates Hilary, Gerdin Anna-Karin, Gkoutos George, Greenaway Simon, Glasl Lisa, Goetz Patrice, Da Cruz Isabelle Goncalves, Götz Alexander, Graw Jochen, Guimond Alain, Hans Wolfgang, Hicks Geoff, Hölter Sabine M, Höfler Heinz, Hancock John M, Hoehndorf Robert, Hough Tertius, Houghton Richard, Hurt Anja, Ivandic Boris, Jacobs Hughes, Jacquot Sylvie, Jones Nora, Karp Natasha A, Katus Hugo A, Kitchen Sharon, Klein-Rodewald Tanja, Klingenspor Martin, Klopstock Thomas, Lalanne Valerie, Leblanc Sophie, Lengger Christoph, le Marchand Elise, Ludwig Tonia, Lux Aline, McKerlie Colin, Maier Holger, Mandel Jean-Louis, Marschall Susan, Mark Manuel, Melvin David G, Meziane Hamid, Micklich Kateryna, Mittelhauser Christophe, Monassier Laurent, Moulaert David, Muller Stéphanie, Naton Beatrix, Neff Frauke, Nolan Patrick M, Nutter Lauryl Mj, Ollert Markus, Pavlovic Guillaume, Pellegata Natalia S, Peter Emilie, Petit-Demoulière Benoit, Pickard Amanda, Podrini Christine, Potter Paul, Pouilly Laurent, Puk Oliver, Richardson David, Rousseau Stephane, Quintanilla-Fend Leticia, Quwailid Mohamed M, Racz Ildiko, Rathkolb Birgit, Riet Fabrice, Rossant Janet, Roux Michel, Rozman Jan, Ryder Ed, Salisbury Jennifer, Santos Luis, Schäble Karl-Heinz, Schiller Evelyn, Schrewe Anja, Schulz Holger, Steinkamp Ralf, Simon Michelle, Stewart Michelle, Stöger Claudia, Stöger Tobias, Sun Minxuan, Sunter David, Teboul Lydia, Tilly Isabelle, Tocchini-Valentini Glauco P, Tost Monica, Treise Irina, Vasseur Laurent, Velot Emilie, Vogt-Weisenhorn Daniela, Wagner Christelle, Walling Alison, Weber Bruno, Wendling Olivia, Westerberg Henrik, Willershäuser Monja, Wolf Eckhard, Wolter Anne, Wood Joe, Wurst Wolfgang, Yildirim Ali Önder, Zeh Ramona, Zimmer Andreas, Zimprich Annemarie, null null, Holmes Chris, Steel Karen P, Herault Yann, Gailus-Durner Valérie, Mallon Ann-Marie, Brown Steve Dm, ;2015;Nature genetics;47;969-978; 26214591

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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