MGI phenotypes (allele matching)
- decreased vertical activity / MGI
B6.Cg-Htr1atm2Rhn/Cnrm
| Status | Available to order |
| EMMA ID | EM:05004 |
| Citation information | RRID:IMSR_EM:05004 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Htr1atm2Rhn/Cnrm |
| Alternative name | Htr1a-STOP-tetO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Htr1atm2Rhn |
| Gene/Transgene symbol | Htr1a |
Information from provider
| Provider | Rene Hen |
| Provider affiliation | Columbia University |
| Additional owner | Dr Cornelius Gross |
| Genetic information | Transcription of the coding region was blocked by the insertion of a neomycin resistance gene and tetO binding sites in the 5' untranslated region. |
| Phenotypic information | Behavior/Neurological: homozygotes display behavioral despair and increased anxiety-related response. |
| Breeding history | The line was backcrossed in C57BL/6J for 15 generations and it is currently maintained by sibling matings. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased anxiety-related response / MGI
- hyperactivity / MGI
- abnormal spatial learning / MGI
- increased dopamine level / MGI
- behavioral despair / MGI
- decreased vertical activity / MGI
- increased thigmotaxis / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- decreased paired-pulse facilitation / MGI
- no phenotypic analysis / MGI
- nervous system phenotype / MGI
- abnormal nervous system physiology / MGI
- abnormal serotonin level / MGI
- behavior/neurological phenotype / MGI
- increased noradrenaline level / MGI
Literature references
- Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult.;Gross Cornelius, Zhuang Xiaoxi, Stark Kimberly, Ramboz Sylvie, Oosting Ronald, Kirby Lynn, Santarelli Luca, Beck Sheryl, Hen René, ;2002;Nature;416;396-400; 11919622