MGI phenotypes (allele matching)
- decreased vertical activity / MGI
B6.Cg-Htr1atm2Rhn/Cnrm
| Status | Available to order |
| EMMA ID | EM:05004 |
| International strain name | B6.Cg-Htr1atm2Rhn/Cnrm |
| Alternative name | Htr1a-STOP-tetO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Htr1atm2Rhn |
| Gene/Transgene symbol | Htr1a |
Information from provider
| Provider | Rene Hen |
| Provider affiliation | Columbia University |
| Additional owner | Dr Cornelius Gross |
| Genetic information | Transcription of the coding region was blocked by the insertion of a neomycin resistance gene and tetO binding sites in the 5' untranslated region. |
| Phenotypic information | Behavior/Neurological: homozygotes display behavioral despair and increased anxiety-related response. |
| Breeding history | The line was backcrossed in C57BL/6J for 15 generations and it is currently maintained by sibling matings. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased anxiety-related response / MGI
- hyperactivity / MGI
- abnormal spatial learning / MGI
- increased dopamine level / MGI
- behavioral despair / MGI
- decreased vertical activity / MGI
- increased thigmotaxis / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- decreased paired-pulse facilitation / MGI
- no phenotypic analysis / MGI
- nervous system phenotype / MGI
- abnormal nervous system physiology / MGI
- abnormal serotonin level / MGI
- behavior/neurological phenotype / MGI
- increased noradrenaline level / MGI
Literature references
- Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult.;Gross Cornelius, Zhuang Xiaoxi, Stark Kimberly, Ramboz Sylvie, Oosting Ronald, Kirby Lynn, Santarelli Luca, Beck Sheryl, Hen René, ;2002;Nature;416;396-400; 11919622