IMPC phenotypes (gene matching)
129-Htr1btm1Rhn/Cnrm
| Status | Available to order |
| EMMA ID | EM:05003 |
| Citation information | RRID:IMSR_EM:05003 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Htr1btm1Rhn/Cnrm |
| Alternative name | Htr1b-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Htr1btm1Rhn |
| Gene/Transgene symbol | Htr1b |
Information from provider
| Provider | Rene Hen |
| Provider affiliation | Columbia University |
| Additional owner | Dr Cornelius Gross, EMBL Mouse Biology Unit, Monterotondo/Rome, Italy |
| Genetic information | The Htr1b gene was disrupted by insertion of a neomycin resistance cassette into the coding region via homologous recombination. |
| Phenotypic information | Behavior/neurological: homozygotes display increased aggression, decreased anxiety-related response, abnormal spatial learning, decreased startle reflex. |
| Breeding history | The line is maintained by sibling matings. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
- increased osteoblast cell number / MGI
- increased bone mass / MGI
- increased bone ossification / MGI
- small testis / MGI
- increased body weight / MGI
- increased aggression towards males / MGI
- decreased anxiety-related response / MGI
- abnormal spatial learning / MGI
- decreased startle reflex / MGI
- abnormal locomotor activation / MGI
- increased fluid intake / MGI
- increased osteoblast proliferation / MGI
- abnormal operant conditioning behavior / MGI
MGI phenotypes (gene matching)
- small testis / MGI
- increased body weight / MGI
- increased aggression towards males / MGI
- decreased anxiety-related response / MGI
- abnormal spatial learning / MGI
- decreased startle reflex / MGI
- abnormal operant conditioning behavior / MGI
- no phenotypic analysis / MGI
- abnormal locomotor activation / MGI
- increased osteoblast cell number / MGI
- increased bone mass / MGI
- increased fluid intake / MGI
- increased bone ossification / MGI
- increased osteoblast proliferation / MGI
Literature references
- Enhanced aggressive behavior in mice lacking 5-HT1B receptor.;Saudou F, Amara D A, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot M C, Hen R, ;1994;Science (New York, N.Y.);265;1875-8; 8091214