129-Htr1btm1Rhn/Cnrm
Status | Available to order |
EMMA ID | EM:05003 |
International strain name | 129-Htr1btm1Rhn/Cnrm |
Alternative name | Htr1b-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Htr1btm1Rhn |
Gene/Transgene symbol | Htr1b |
Information from provider
Provider | Rene Hen |
Provider affiliation | Columbia University |
Additional owner | Dr Cornelius Gross, EMBL Mouse Biology Unit, Monterotondo/Rome, Italy |
Genetic information | The Htr1b gene was disrupted by insertion of a neomycin resistance cassette into the coding region via homologous recombination. |
Phenotypic information | Behavior/neurological: homozygotes display increased aggression, decreased anxiety-related response, abnormal spatial learning, decreased startle reflex. |
Breeding history | The line is maintained by sibling matings. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- increased osteoblast cell number / MGI
- increased bone mass / MGI
- increased bone ossification / MGI
- small testis / MGI
- increased body weight / MGI
- increased aggression towards males / MGI
- decreased anxiety-related response / MGI
- abnormal spatial learning / MGI
- decreased startle reflex / MGI
- abnormal locomotor activation / MGI
- increased fluid intake / MGI
- increased osteoblast proliferation / MGI
- abnormal operant conditioning behavior / MGI
MGI phenotypes (gene matching)
- small testis / MGI
- increased body weight / MGI
- increased aggression towards males / MGI
- decreased anxiety-related response / MGI
- abnormal spatial learning / MGI
- decreased startle reflex / MGI
- abnormal operant conditioning behavior / MGI
- no phenotypic analysis / MGI
- abnormal locomotor activation / MGI
- increased osteoblast cell number / MGI
- increased bone mass / MGI
- increased fluid intake / MGI
- increased bone ossification / MGI
- increased osteoblast proliferation / MGI
Literature references
- Enhanced aggressive behavior in mice lacking 5-HT1B receptor.;Saudou F, Amara D A, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot M C, Hen R, ;1994;Science (New York, N.Y.);265;1875-8; 8091214
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