B6.129-Slc6a4tm1Kpl/Cnrm

Status

Available to order

EMMA IDEM:05002
International strain nameB6.129-Slc6a4tm1Kpl/Cnrm
Alternative nameSERT-KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolSlc6a4tm1Kpl
Gene/Transgene symbolSlc6a4

Information from provider

ProviderKlaus-Peter Lesch
Provider affiliationMollecular Psychiatry, University of Wurzburg
Additional ownerDr Cornelius Gross, EMBL Mouse Biology Unit, Monterotondo/Rome, Italy
Genetic informationA neomycin selection cassette replaced a DNA segment containing exon 2 of the Slc6a4 (serotonin transporter, Sert) gene.
Phenotypic informationBehavior/Neurological: homozygotes display behavioral despair, decreased exploration in new environment, enhanced conditioned place preference, abnormal response to novel object, abnormal serotonin concentration, abnormal thermal nociception, abnormal sleep pattern.
Breeding historyThe line was backcrossed in C57BL/6J for 10 generations and it is currently maintained by siblings breedings.
References
  • Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.;Bengel D, Murphy D L, Andrews A M, Wichems C H, Feltner D, Heils A, Mössner R, Westphal H, Lesch K P, ;1998;Molecular pharmacology;53;649-55; 9547354
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • megacephaly / MGI
  • abnormal social investigation / MGI
  • increased brain weight / MGI
  • abnormal barrel cortex morphology / MGI
  • enhanced conditioned place preference behavior / MGI
  • hyperactivity / MGI
  • social withdrawal / MGI
  • decreased exploration in new environment / MGI
  • behavioral despair / MGI
  • abnormal response to novel object / MGI
  • abnormal heart valve morphology / MGI
  • dilated cardiomyopathy / MGI
  • cardiac fibrosis / MGI
  • heart valve hyperplasia / MGI
  • decreased cardiac muscle contractility / MGI
  • abnormal serotonin level / MGI
  • heart right ventricle hypertrophy / MGI
  • abnormal pulmonary artery morphology / MGI
  • abnormal sleep pattern / MGI
  • abnormal brain morphology / MGI
  • abnormal thermal nociception / MGI
  • abnormal heart ventricle morphology / MGI
  • increased right ventricle systolic pressure / MGI
  • hypoactivity / MGI
  • abnormal body temperature homeostasis / MGI
MGI phenotypes (gene matching)
  • heart right ventricle hypertrophy / MGI
  • abnormal heart valve morphology / MGI
  • megacephaly / MGI
  • abnormal pulmonary artery morphology / MGI
  • abnormal social investigation / MGI
  • social withdrawal / MGI
  • abnormal anxiety-related response / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • abnormal response to new environment / MGI
  • decreased exploration in new environment / MGI
  • abnormal sleep pattern / MGI
  • abnormal body temperature homeostasis / MGI
  • abnormal fear/anxiety-related behavior / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • increased brain weight / MGI
  • behavioral despair / MGI
  • abnormal thermal nociception / MGI
  • dilated cardiomyopathy / MGI
  • abnormal active avoidance behavior / MGI
  • cardiac fibrosis / MGI
  • abnormal response to novel object / MGI
  • abnormal serotonergic neuron morphology / MGI
  • heart valve hyperplasia / MGI
  • abnormal barrel cortex morphology / MGI
  • abnormal neuron physiology / MGI
  • decreased cardiac muscle contractility / MGI
  • abnormal heart ventricle morphology / MGI
  • growth/size/body region phenotype / MGI
  • abnormal action potential / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • enhanced conditioned place preference behavior / MGI
  • impaired behavioral response to xenobiotic / MGI
  • decreased serotonin level / MGI
  • increased right ventricle systolic pressure / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI

Literature references

  • Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.;Bengel D, Murphy D L, Andrews A M, Wichems C H, Feltner D, Heils A, Mössner R, Westphal H, Lesch K P, ;1998;Molecular pharmacology;53;649-55; 9547354

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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