B6.129-Slc6a4^tm1Kpl/Cnrm

Status	Available to order
EMMA ID	EM:05002
Citation information	RRID:IMSR_EM:05002 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129-Slc6a4^tm1Kpl/Cnrm
Alternative name	SERT-KO
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Slc6a4^tm1Kpl
Gene/Transgene symbol	Slc6a4

Information from provider

Provider	Klaus-Peter Lesch
Provider affiliation	Mollecular Psychiatry, University of Wurzburg
Additional owner	Dr Cornelius Gross, EMBL Mouse Biology Unit, Monterotondo/Rome, Italy
Genetic information	A neomycin selection cassette replaced a DNA segment containing exon 2 of the Slc6a4 (serotonin transporter, Sert) gene.
Phenotypic information	Behavior/Neurological: homozygotes display behavioral despair, decreased exploration in new environment, enhanced conditioned place preference, abnormal response to novel object, abnormal serotonin concentration, abnormal thermal nociception, abnormal sleep pattern.
Breeding history	The line was backcrossed in C57BL/6J for 10 generations and it is currently maintained by siblings breedings.
References	Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.;Bengel D, Murphy D L, Andrews A M, Wichems C H, Feltner D, Heils A, Mössner R, Westphal H, Lesch K P, ;1998;Molecular pharmacology;53;649-55; 9547354
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

autistic disorder / DOID:12849

MGI phenotypes (allele matching)

megacephaly / MGI
abnormal social investigation / MGI
increased brain weight / MGI
abnormal barrel cortex morphology / MGI
enhanced conditioned place preference behavior / MGI
hyperactivity / MGI
social withdrawal / MGI
decreased exploration in new environment / MGI
behavioral despair / MGI
abnormal response to novel object / MGI
abnormal heart valve morphology / MGI
dilated cardiomyopathy / MGI
cardiac fibrosis / MGI
heart valve hyperplasia / MGI
decreased cardiac muscle contractility / MGI
abnormal serotonin level / MGI
heart right ventricle hypertrophy / MGI
abnormal pulmonary artery morphology / MGI
abnormal sleep pattern / MGI
abnormal brain morphology / MGI
abnormal thermal nociception / MGI
abnormal heart ventricle morphology / MGI
increased right ventricle systolic pressure / MGI
hypoactivity / MGI
abnormal body temperature homeostasis / MGI

MGI phenotypes (gene matching)

heart right ventricle hypertrophy / MGI
abnormal heart valve morphology / MGI
megacephaly / MGI
abnormal pulmonary artery morphology / MGI
abnormal social investigation / MGI
social withdrawal / MGI
abnormal anxiety-related response / MGI
hyperactivity / MGI
hypoactivity / MGI
abnormal response to new environment / MGI
decreased exploration in new environment / MGI
abnormal sleep pattern / MGI
abnormal body temperature homeostasis / MGI
abnormal fear/anxiety-related behavior / MGI
abnormal brain morphology / MGI
no abnormal phenotype detected / MGI
increased brain weight / MGI
behavioral despair / MGI
abnormal thermal nociception / MGI
dilated cardiomyopathy / MGI
abnormal active avoidance behavior / MGI
cardiac fibrosis / MGI
abnormal response to novel object / MGI
abnormal serotonergic neuron morphology / MGI
heart valve hyperplasia / MGI
abnormal barrel cortex morphology / MGI
abnormal neuron physiology / MGI
decreased cardiac muscle contractility / MGI
abnormal heart ventricle morphology / MGI
growth/size/body region phenotype / MGI
abnormal action potential / MGI
decreased physiological sensitivity to xenobiotic / MGI
enhanced conditioned place preference behavior / MGI
impaired behavioral response to xenobiotic / MGI
decreased serotonin level / MGI
increased right ventricle systolic pressure / MGI
mortality/aging / MGI
postnatal lethality, incomplete penetrance / MGI

Literature references

Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.;Bengel D, Murphy D L, Andrews A M, Wichems C H, Feltner D, Heils A, Mössner R, Westphal H, Lesch K P, ;1998;Molecular pharmacology;53;649-55; 9547354

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6.129-Slc6a4tm1Kpl/Cnrm