B6;CBA-Tg(TNF)197Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:04975 |
| Citation information | RRID:IMSR_EM:04975 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;CBA-Tg(TNF)197Gkl/Flmg |
| Alternative name | B6;CBA-Tg(TNF-HBB)197Gkl/Flmg, B6;CBA-Tg(huTNF)197Gkl/Flmg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(TNF)197Gkl |
| Gene/Transgene symbol | Tg(TNF)197Gkl |
Information from provider
| Provider | George Kollias |
| Provider affiliation | B.S.R.C. |
| Genetic information | The human TNF/beta-globin (TNF-globin) recombinant gene construct was prepared in the pBluescript vector as follows: The 2.8 kb EcoRI fragment which contains the entire coding region of the human TNF gene was ligated to the 0.77 kb EcoRI-Sall fragment which contains the 3'-untranslated region and polyadenylation site of the human beta-globin gene (Kollias et al., 1987) and excised for microinjection as a BamHI -Sall fragment. |
| Phenotypic information | Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous males, wild-type females |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.;Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G, ;1991;The EMBO journal;10;4025-31; 1721867
- Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment.;Ntari Lydia, Nikolaou Christoforos, Kranidioti Ksanthi, Papadopoulou Dimitra, Christodoulou-Vafeiadou Eleni, Chouvardas Panagiotis, Meier Florian, Geka Christina, Denis Maria C, Karagianni Niki, Kollias George, ;2021;Journal of translational medicine;19;165; 33892739