129S5.Cg-Med31l11Jus15 +/+ In(11Trp53;11Wnt3)8Brd/H

Status

Available to order

EMMA IDEM:04964
Citation informationRRID:IMSR_EM:04964 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain name129S5.Cg-Med31l11Jus15 +/+ In(11Trp53;11Wnt3)8Brd/H
Alternative nameMed31l11Jus15
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolMed31l11Jus15, In(11Trp53;11Wnt3)8Brd
Gene/Transgene symbolMed31, In(11Trp53;11Wnt3)8Brd

Information from provider

ProviderKathryn Hentges
Provider affiliationPaterson Institute for Cancer Research, University of Manchester
Additional ownerProf. Monica Justice, Baylor College of Medicine, Houston, Texas, USA
Genetic informationENU induced point mutation in Med31 causing premature stop codon. Truncated protein is unstable.
Phenotypic informationEmbryonic lethality with reduced cell proliferation rates in embryonic fibroblasts.
Breeding historyOutcrossed 8 generations to 129S5. Maintained as balanced stock with chromosome 11 balancer chromosome described in Kile et al., 2003 Nature 425:81-6.
ReferencesNone available
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous 129S5/SvEvBrd males
Breeding at archiving centreMales were archived upon arrival at the archiving centre. No breeding was performed.

Disease and phenotype information

MGI phenotypes (allele matching)
  • prenatal lethality, complete penetrance / MGI
  • abnormal cartilage development / MGI
  • decreased cell proliferation / MGI
  • decreased embryo size / MGI
  • edema / MGI
  • spina bifida / MGI
  • pallor / MGI
  • embryonic growth retardation / MGI
  • decreased fetal size / MGI
  • small cranium / MGI
  • hearing/vestibular/ear phenotype / MGI
  • cardiovascular system phenotype / MGI
  • abnormal skeleton morphology / MGI
  • abnormal limb development / MGI
  • small thoracic cage / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • decreased fibroblast proliferation / MGI
  • decreased bone ossification / MGI
  • open neural tube / MGI
  • abnormal embryonic growth/weight/body size / MGI
MGI phenotypes (gene matching)
  • abnormal cartilage development / MGI
  • decreased cell proliferation / MGI
  • open neural tube / MGI
  • decreased embryo size / MGI
  • edema / MGI
  • abnormal embryonic growth/weight/body size / MGI
  • spina bifida / MGI
  • pallor / MGI
  • embryonic growth retardation / MGI
  • decreased fetal size / MGI
  • small cranium / MGI
  • hearing/vestibular/ear phenotype / MGI
  • cardiovascular system phenotype / MGI
  • abnormal skeleton morphology / MGI
  • abnormal limb development / MGI
  • small thoracic cage / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • decreased fibroblast proliferation / MGI
  • decreased bone ossification / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).