- abnormal cerebellar granule layer morphology / MGI
- abnormal trigeminal nerve morphology / MGI
- abnormal lipid homeostasis / MGI
- abnormal hippocampal fimbria morphology / MGI
- increased hepatocellular carcinoma incidence / MGI
- abnormal myelin sheath morphology / MGI
- increased liver tumor incidence / MGI
- abnormal brain white matter morphology / MGI
- integument phenotype / MGI
B6;129S4-Cers2Gt(S16-4B1)Sor/Cnrm
Status | Available to order |
EMMA ID | EM:04933 |
International strain name | B6;129S4-Cers2Gt(S16-4B1)Sor/Cnrm |
Alternative name | CerS2 gene trap |
Strain type | Gene-trap |
Allele/Transgene symbol | Cers2Gt(S16-4B1)Sor |
Gene/Transgene symbol | Cers2 |
Information from provider
Provider | Klaus WILLECKE |
Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
Genetic information | A gene-trap (Rosafary) is inserted into intron 1 of Cers2 (Lass2), leading to the disruption of Cers2 expression. Instead, a lacZ reporter gene is expressed under control of the Cers2 promoter. The hygromycin resistance cassette was removed via flp recombinase-mediated recombination. |
Phenotypic information | Adult homozygous Cers2 gene-trap mice are smaller than their wild-type littermates. They develop liver carcinomas and show myelin degeneration. |
Breeding history | The first heterozygous offspring of chimeras were backcrossed three times with C57BL/6. Cers2 gene-trap mice are currently mated to C57BL/6 or inbred. |
References |
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Homozygous fertile | not known |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal cerebellar granule layer morphology / MGI
- abnormal trigeminal nerve morphology / MGI
- abnormal lipid homeostasis / MGI
- abnormal hippocampal fimbria morphology / MGI
- increased hepatocellular carcinoma incidence / MGI
- abnormal myelin sheath morphology / MGI
- increased liver tumor incidence / MGI
- abnormal brain white matter morphology / MGI
- integument phenotype / MGI
Literature references
- Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas.;Imgrund Silke, Hartmann Dieter, Farwanah Hany, Eckhardt Matthias, Sandhoff Roger, Degen Joachim, Gieselmann Volkmar, Sandhoff Konrad, Willecke Klaus, ;2009;The Journal of biological chemistry;284;33549-60; 19801672
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