| Status | Available to order |
| EMMA ID | EM:04933 |
| Citation information | RRID:IMSR_EM:04933 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S4-Cers2Gt(S16-4B1)Sor/Cnrm |
| Alternative name | CerS2 gene trap |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Cers2Gt(S16-4B1)Sor |
| Gene/Transgene symbol | Cers2 |
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | A gene-trap (Rosafary) is inserted into intron 1 of Cers2 (Lass2), leading to the disruption of Cers2 expression. Instead, a lacZ reporter gene is expressed under control of the Cers2 promoter. The hygromycin resistance cassette was removed via flp recombinase-mediated recombination. |
| Phenotypic information | Adult homozygous Cers2 gene-trap mice are smaller than their wild-type littermates. They develop liver carcinomas and show myelin degeneration. |
| Breeding history | The first heterozygous offspring of chimeras were backcrossed three times with C57BL/6. Cers2 gene-trap mice are currently mated to C57BL/6 or inbred. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
