IMPC phenotypes (allele matching)
CBACa;129P2-Ube3bGt(RRJ142)Byg/WtsiCnbc
| Status | Available to order |
| EMMA ID | EM:04922 |
| Citation information | RRID:IMSR_EM:04922 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CBACa;129P2-Ube3bGt(RRJ142)Byg/WtsiCnbc |
| Alternative name | Ube3b genetrap |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Ube3bGt(RRJ142)Byg |
| Gene/Transgene symbol | Ube3b |
Information from provider
| Provider | Karen Steel |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | A genetrap from BayGenomics in the Ube3b gene. |
| Phenotypic information | Homozygotes have reduced viability and show reduced body weight, reduced lipid levels, hot plate and grip strength anomalies (see Wellcome Trust Sanger Institute phenotyping data on web). |
| Breeding history | Chimaeras from the 129P2 ES cells were mated with CBA/Ca and then the colony maintained by intercrossing. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Oculocerebrofacial syndrome, Kaufman type / Orphanet_2707
IMPC phenotypes (gene matching)
- preweaning lethality, incomplete penetrance / IMPC
- abnormal embryo size / IMPC
- decreased body weight / IMPC
- decreased circulating HDL cholesterol level / IMPC
- increased cornea thickness / IMPC
- fused cornea and lens / IMPC
- abnormal lens morphology / IMPC
- preweaning lethality, complete penetrance / IMPC
- eye hemorrhage / IMPC
- abnormal facial morphology / IMPC
- abnormal cornea morphology / IMPC
- abnormal iris morphology / IMPC
- iris synechia / IMPC
- abnormal eye anterior chamber depth / IMPC
- decreased circulating cholesterol level / IMPC
- trunk curl / IMPC
- abnormal retina inner nuclear layer morphology / IMPC
- decreased circulating LDL cholesterol level / IMPC
MGI phenotypes (allele matching)
- decreased circulating LDL cholesterol level / MGI
- decreased brain size / MGI
- decreased body weight / MGI
- decreased body size / MGI
- eye inflammation / MGI
- reduced fertility / MGI
- nervous system phenotype / MGI
- lymphangiectasis / MGI
- decreased circulating cholesterol level / MGI
- hearing/vestibular/ear phenotype / MGI
- calcified retina / MGI
- impaired hearing / MGI
- small hippocampus / MGI
- decreased grip strength / MGI
- preweaning lethality, incomplete penetrance / MGI
- decreased dentate gyrus size / MGI
MGI phenotypes (gene matching)
- decreased circulating LDL cholesterol level / MGI
- decreased brain size / MGI
- decreased body weight / MGI
- decreased body size / MGI
- eye inflammation / MGI
- reduced fertility / MGI
- nervous system phenotype / MGI
- lymphangiectasis / MGI
- decreased circulating cholesterol level / MGI
- hearing/vestibular/ear phenotype / MGI
- calcified retina / MGI
- impaired hearing / MGI
- small hippocampus / MGI
- decreased grip strength / MGI
- preweaning lethality, incomplete penetrance / MGI
- decreased dentate gyrus size / MGI