C3HeB/FeJ-Jag1Mhdahtu/IegWtsiCnbc

Status

Available to order

EMMA IDEM:04920
International strain nameC3HeB/FeJ-Jag1Mhdahtu/IegWtsiCnbc
Alternative nameHeadturner, Jag1
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolJag1Mhdahtu
Gene/Transgene symbolJag1

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Additional ownerProf. M. Hrabé de Angelis, Helmholtz Zentrum München, Neuherberg, Germany
Genetic informationENU-induced mutation of Jag1. Strains EM:00199 and EM:04920 carry the same mutant allele. Strain EM:00199 has been backcrossed around 5 times to C3HeB/FeJ. Strain EM:04920 has possibly been further backcrossed 1/2 times to C3HeB/FeJ.
Phenotypic informationHeterozygotes show head bobbing and homozygotes die in mid-gestation.
Breeding historyOriginated from ENU mutagenesis programme in Munich, Helmholtz Centrum, on a C3HeB/FeJ background and bred on the same background within a closed colony or backcrossed to C3HeB/FeJ ever since.
References
  • The Notch ligand Jagged1 is required for inner ear sensory development.;Kiernan A E, Ahituv N, Fuchs H, Balling R, Avraham K B, Steel K P, Hrabé de Angelis M, ;2001;Proceedings of the National Academy of Sciences of the United States of America;98;3873-8; 11259677
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal organ of Corti morphology / MGI
  • abnormal semicircular canal morphology / MGI
  • abnormal cochlear hair cell morphology / MGI
  • head shaking / MGI
  • abnormal crista ampullaris morphology / MGI
  • increased cochlear inner hair cell number / MGI
  • decreased cochlear outer hair cell number / MGI
  • head tossing / MGI
  • hearing/vestibular/ear phenotype / MGI
  • abnormal semicircular canal ampulla morphology / MGI
  • enlarged pericardium / MGI
  • abnormal blood vessel morphology / MGI
  • hemorrhage / MGI
  • abnormal vitelline vasculature morphology / MGI
  • kinked neural tube / MGI
  • embryonic growth retardation / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryonic lethality during organogenesis / MGI
  • embryo tissue necrosis / MGI
MGI phenotypes (gene matching)
  • abnormal organ of Corti morphology / MGI
  • abnormal vascular development / MGI
  • enlarged pericardium / MGI
  • distended pericardium / MGI
  • corneal opacity / MGI
  • irregularly shaped pupil / MGI
  • head bobbing / MGI
  • impaired balance / MGI
  • abnormal blood vessel morphology / MGI
  • pale yolk sac / MGI
  • hemorrhage / MGI
  • intracranial hemorrhage / MGI
  • abnormal eye morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal semicircular canal morphology / MGI
  • abnormal cochlear hair cell morphology / MGI
  • head shaking / MGI
  • abnormal posterior semicircular canal morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal superior semicircular canal morphology / MGI
  • abnormal vitelline vasculature morphology / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • kinked neural tube / MGI
  • embryonic growth retardation / MGI
  • abnormal vitelline vascular remodeling / MGI
  • abnormal crista ampullaris morphology / MGI
  • increased cochlear inner hair cell number / MGI
  • decreased cochlear outer hair cell number / MGI
  • decreased neuronal precursor cell number / MGI
  • head tossing / MGI
  • positive geotaxis / MGI
  • hearing/vestibular/ear phenotype / MGI
  • embryonic lethality during organogenesis / MGI
  • abnormal placement of pupils / MGI
  • abnormal semicircular canal ampulla morphology / MGI
  • increased neuron number / MGI
  • abnormal neuron differentiation / MGI
  • iris coloboma / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryo tissue necrosis / MGI

Literature references

  • The Notch ligand Jagged1 is required for inner ear sensory development.;Kiernan A E, Ahituv N, Fuchs H, Balling R, Avraham K B, Steel K P, Hrabé de Angelis M, ;2001;Proceedings of the National Academy of Sciences of the United States of America;98;3873-8; 11259677

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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