C3HeB/FeJ-Crsl/IegWtsiCnbc

Status

Available to order

EMMA IDEM:04919
International strain nameC3HeB/FeJ-Crsl/IegWtsiCnbc
Alternative nameCarousel
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolCrsl
Gene/Transgene symbolCrsl

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Additional ownerProf. M. Hrabé de Angelis, Helmholtz Zentrum München, Neuherberg, Germany
Genetic informationENU-induced mutation at proximal chromosome 4.
Phenotypic informationCircling, head-bobbing and hyperactive mutant, maps to proximal chromosome 4. Phenotype indistinguishable from Chd7 mutations.
Breeding historyOriginated from ENU mutagenesis programme in Munich, Helmholtz Centrum, on a C3HeB/FeJ background and bred on the same background within a closed colony or backcrossed to C3HeB/FeJ ever since.
References
  • Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4.;Hawker Kelvin, Fuchs Helmut, Angelis Martin Hrabéde, Steel Karen P, ;2005;International journal of audiology;44;171-7; 15916118
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

MGI phenotypes (allele matching)
  • dry eyes / MGI
  • postnatal lethality / MGI
  • abnormal external female genitalia morphology / MGI
  • clitoris hypoplasia / MGI
  • keratoconjunctivitis sicca / MGI
  • circling / MGI
  • hyperactivity / MGI
  • head bobbing / MGI
  • abnormal superior semicircular canal morphology / MGI
  • absent lateral semicircular canal / MGI
  • decreased lateral semicircular canal size / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • abnormal round window morphology / MGI
  • abnormal stapes morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • skeleton phenotype / MGI
MGI phenotypes (gene matching)
  • dry eyes / MGI
  • circling / MGI
  • hyperactivity / MGI
  • head bobbing / MGI
  • postnatal lethality / MGI
  • abnormal superior semicircular canal morphology / MGI
  • abnormal external female genitalia morphology / MGI
  • absent lateral semicircular canal / MGI
  • decreased lateral semicircular canal size / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • abnormal round window morphology / MGI
  • abnormal stapes morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • skeleton phenotype / MGI
  • clitoris hypoplasia / MGI
  • keratoconjunctivitis sicca / MGI

Literature references

  • Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4.;Hawker Kelvin, Fuchs Helmut, Angelis Martin Hrabéde, Steel Karen P, ;2005;International journal of audiology;44;171-7; 15916118

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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