C3HeB/FeJ-Crsl/IegWtsiCnbc

Status

Available to order

EMMA IDEM:04919
Citation informationRRID:IMSR_EM:04919 

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International strain nameC3HeB/FeJ-Crsl/IegWtsiCnbc
Alternative nameCarousel
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolCrsl
Gene/Transgene symbolCrsl

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Additional ownerProf. M. Hrabé de Angelis, Helmholtz Zentrum München, Neuherberg, Germany
Genetic informationENU-induced mutation at proximal chromosome 4.
Phenotypic informationCircling, head-bobbing and hyperactive mutant, maps to proximal chromosome 4. Phenotype indistinguishable from Chd7 mutations.
Breeding historyOriginated from ENU mutagenesis programme in Munich, Helmholtz Centrum, on a C3HeB/FeJ background and bred on the same background within a closed colony or backcrossed to C3HeB/FeJ ever since.
References
  • Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4.;Hawker Kelvin, Fuchs Helmut, Angelis Martin Hrabéde, Steel Karen P, ;2005;International journal of audiology;44;171-7; 15916118
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

MGI phenotypes (allele matching)
  • dry eyes / MGI
  • postnatal lethality / MGI
  • abnormal external female genitalia morphology / MGI
  • clitoris hypoplasia / MGI
  • keratoconjunctivitis sicca / MGI
  • circling / MGI
  • hyperactivity / MGI
  • head bobbing / MGI
  • abnormal superior semicircular canal morphology / MGI
  • absent lateral semicircular canal / MGI
  • decreased lateral semicircular canal size / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • abnormal round window morphology / MGI
  • abnormal stapes morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • skeleton phenotype / MGI
MGI phenotypes (gene matching)
  • dry eyes / MGI
  • circling / MGI
  • hyperactivity / MGI
  • head bobbing / MGI
  • postnatal lethality / MGI
  • abnormal superior semicircular canal morphology / MGI
  • abnormal external female genitalia morphology / MGI
  • absent lateral semicircular canal / MGI
  • decreased lateral semicircular canal size / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • abnormal round window morphology / MGI
  • abnormal stapes morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • skeleton phenotype / MGI
  • clitoris hypoplasia / MGI
  • keratoconjunctivitis sicca / MGI

Literature references

  • Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4.;Hawker Kelvin, Fuchs Helmut, Angelis Martin Hrabéde, Steel Karen P, ;2005;International journal of audiology;44;171-7; 15916118

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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