B6.Cg-Tg(CEACAM5-Tag)L5496Wzm/Cnrm
| Status | Available to order |
| EMMA ID | EM:00049 |
| International strain name | B6.Cg-Tg(CEACAM5-Tag)L5496Wzm/Cnrm |
| Alternative name | CEA-5496 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CEACAM5-Tag)L5496Wzm |
| Gene/Transgene symbol | Tg(CEACAM5-Tag)L5496Wzm |
Information from provider
| Provider | Wolfgang Zimmermann |
| Provider affiliation | Max Planck Institute of Immunobiology |
| Genetic information | Expressed transgene: 424 bp (upstream of translational start) promoter region of human CEACAM5 gene upstream of Simian virus 40 large tumor antigen (SV40 TAg). |
| Phenotypic information | Animals die at an age of 100-120 days probably from starvation (probably caused by closure of pylorus/duodenum by ingrowing tumor); 100% of the mice (5-6 weeks of age) develop invasive stomach adenocarcinomas. |
| Breeding history | Backcrossed to C57BL/6 (more than 20 generations). |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- A transgenic mouse line that develops early-onset invasive gastric carcinoma provides a model for carcinoembryonic antigen-targeted tumor therapy.;Thompson J, Epting T, Schwarzkopf G, Singhofen A, Eades-Perner A M, van Der Putten H, Zimmermann W, ;2000;International journal of cancer;86;863-9; 10842202