B6.Cg-Tg(CEACAM5-Tag)L5496Wzm/Cnrm
| Status | Available to order |
| EMMA ID | EM:00049 |
| Citation information | RRID:IMSR_EM:00049 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(CEACAM5-Tag)L5496Wzm/Cnrm |
| Alternative name | CEA-5496 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CEACAM5-Tag)L5496Wzm |
| Gene/Transgene symbol | Tg(CEACAM5-Tag)L5496Wzm |
Information from provider
| Provider | Wolfgang Zimmermann |
| Provider affiliation | Max Planck Institute of Immunobiology |
| Genetic information | Expressed transgene: 424 bp (upstream of translational start) promoter region of human CEACAM5 gene upstream of Simian virus 40 large tumor antigen (SV40 TAg). |
| Phenotypic information | Animals die at an age of 100-120 days probably from starvation (probably caused by closure of pylorus/duodenum by ingrowing tumor); 100% of the mice (5-6 weeks of age) develop invasive stomach adenocarcinomas. |
| Breeding history | Backcrossed to C57BL/6 (more than 20 generations). |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- A transgenic mouse line that develops early-onset invasive gastric carcinoma provides a model for carcinoembryonic antigen-targeted tumor therapy.;Thompson J, Epting T, Schwarzkopf G, Singhofen A, Eades-Perner A M, van Der Putten H, Zimmermann W, ;2000;International journal of cancer;86;863-9; 10842202