STOCK Lmx1amtl/Cnbc

Status

Available to order

EMMA IDEM:04898
Citation informationRRID:IMSR_EM:04898 

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International strain nameSTOCK Lmx1amtl/Cnbc
Alternative nameMutanlallemande
Strain typeSpontaneous
Allele/Transgene symbolLmx1amtl
Gene/Transgene symbolLmx1a

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Additional ownerYvan Lallemand and Jean-Louis Guenet, Institut Pasteur, discovered the mutant.
Genetic informationA spontaneous mutation of Lmx1a.
Phenotypic informationHomozygotes show severe head bobbing and circling, white belly spot or belt and are small.
Breeding historyThe mutant was introduced on a mixed genetic background and has been maintained within a closed colony for over ten years.
ReferencesNone available
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

MGI phenotypes (allele matching)
  • belly spot / MGI
  • impaired hearing / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • abnormal inner ear morphology / MGI
  • absent semicircular canals / MGI
  • short tail / MGI
  • hyperactivity / MGI
  • impaired righting response / MGI
  • abnormal placing response / MGI
  • deafness / MGI
  • absent otoliths / MGI
  • abnormal cochlear inner hair cell morphology / MGI
  • abnormal vestibular labyrinth morphology / MGI
  • head tossing / MGI
  • dilated endolymphatic duct / MGI
  • dilated endolymphatic sac / MGI
  • abnormal otic vesicle development / MGI
  • abnormal vestibular saccule morphology / MGI
  • abnormal utricle morphology / MGI
  • absent pinna reflex / MGI
  • short scala media / MGI
MGI phenotypes (gene matching)
  • abnormal inner ear morphology / MGI
  • abnormal cochlea morphology / MGI
  • abnormal inner ear vestibule morphology / MGI
  • abnormal membranous labyrinth morphology / MGI
  • absent semicircular canals / MGI
  • abnormal interparietal bone morphology / MGI
  • abnormal parietal bone morphology / MGI
  • abnormal cell proliferation / MGI
  • belly spot / MGI
  • synostosis / MGI
  • kinked tail / MGI
  • short tail / MGI
  • decreased brain size / MGI
  • abnormal hippocampus development / MGI
  • abnormal cerebellum morphology / MGI
  • small cerebellum / MGI
  • abnormal cerebellum development / MGI
  • abnormal cerebellar foliation / MGI
  • abnormal cerebellum posterior vermis morphology / MGI
  • abnormal roof plate morphology / MGI
  • abnormal rhombomere morphology / MGI
  • abnormal glossopharyngeal nerve morphology / MGI
  • abnormal glossopharyngeal ganglion morphology / MGI
  • uterus hypoplasia / MGI
  • decreased body size / MGI
  • ataxia / MGI
  • circling / MGI
  • bidirectional circling / MGI
  • hyperactivity / MGI
  • abnormal motor coordination/balance / MGI
  • impaired righting response / MGI
  • abnormal placing response / MGI
  • hydroencephaly / MGI
  • infertility / MGI
  • male infertility / MGI
  • female infertility / MGI
  • deafness / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • abnormal neural tube morphology / MGI
  • abnormal fertility/fecundity / MGI
  • abnormal semicircular canal morphology / MGI
  • belted / MGI
  • altered righting response / MGI
  • white spotting / MGI
  • absent otoliths / MGI
  • no phenotypic analysis / MGI
  • spina bifida / MGI
  • abnormal cell migration / MGI
  • abnormal ear development / MGI
  • abnormal bony labyrinth / MGI
  • absent vestibular saccule / MGI
  • absent utricle / MGI
  • abnormal cochlear inner hair cell morphology / MGI
  • abnormal cochlear labyrinth morphology / MGI
  • abnormal vestibular labyrinth morphology / MGI
  • syndromic hearing loss / MGI
  • abnormal vertebral arch development / MGI
  • head tossing / MGI
  • abnormal cell physiology / MGI
  • dilated endolymphatic duct / MGI
  • dilated endolymphatic sac / MGI
  • abnormal otic vesicle development / MGI
  • abnormal vestibular saccule morphology / MGI
  • abnormal utricle morphology / MGI
  • abnormal tail development / MGI
  • inner ear hypoplasia / MGI
  • impaired hearing / MGI
  • absent pinna reflex / MGI
  • abnormal hippocampus CA3 region morphology / MGI
  • abnormal hippocampus pyramidal cell layer / MGI
  • short scala media / MGI
  • bleb / MGI
  • abnormal resting posture / MGI
  • reduced cerebellar foliation / MGI
  • abnormal neuron differentiation / MGI
  • mortality/aging / MGI
  • prenatal lethality, complete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • decreased dopaminergic neuron number / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • abnormal rhombomere 3 morphology / MGI
  • abnormal rhombomere 4 morphology / MGI
  • abnormal rhombomere 5 morphology / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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